DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and CG18233

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	148/520 - (28%)
Similarity:	264/520 - (50%)	Gaps:	40/520 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NGEVY-TALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREHSDASHDITAYVSNP 85
            |.:.| :::..:.:||:.|...:.|...|..:.::|::.|...:|..:|.:....::...:||||
  Fly    27 NRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNP 91

  Fly    86 INAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLK-FPSDEDLNGAAVALLRLQDTYQL 149
            :||:.|.:||..||.:::|..:..:|   |:.:|..:.::. .|...|:|....|:.|::.||.|
  Fly    92 LNAFGLIRRLNQDWPKLQNYTQKPLG---LEQLTAMQDIVSAAPESFDMNEKLKAMHRIETTYDL 153

  Fly   150 DTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARMLEEPTNHTQSFTKA 214
            ....:|:|.|...:::..:...||..|....:...::..::||..||: ::..:.:....:..|.
  Fly   154 QPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEAL-KLSTDGSLEIMNRLKE 217

  Fly   215 DILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQLQLRKMKGDDGTDEM 279
            ..|:..|.:..|.....|...:|||.:..:.:.:..:......|:.|:.  :|::...||.|  .
  Fly   218 IELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISS--ELKQWINDDST--T 278

  Fly   280 PKSDLPVAKSDPAIFDMTERRAYEMLCRGELKPSPSDLRSLRCRYVTNRVPFLRLGPLKLEEVHA 344
            |.:|                  :.:.||| |.|..|   :|.|||.::...||:|.|||:||:..
  Fly   279 PPTD------------------HNLGCRG-LFPKKS---NLVCRYNSSTNAFLKLAPLKMEEISR 321

  Fly   345 DPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYRISKSAWLKTQEDRVIETVV 409
            |||||::|:.:.|.:|:.:|.      ....::|..| :|......:|:..|:: :|....:.:.
  Fly   322 DPYIVMFHEVISDKDIEEMKG------EITEMENGWT-SLGDPKEIVSRVYWIR-KESSFSKRIN 378

  Fly   410 QRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGLNLGNRIATVLFYMSDVEQG 474
            ||.:||||..::....:|:.|:|:||:::||:||.....:.......||:||.:::||..:|.||
  Fly   379 QRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTLGDRIGSIIFYAGEVSQG 443

  Fly   475 GATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNKWIHERGQEFRRPC 539
            |.|||..|..|:.||||.|.||.|...|...|.|:.|:.||||.|::|...||:|...|.|.:||
  Fly   444 GQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508

Fly 540 539
Fly 509 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	34/131 (26%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	59/172 (34%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	34/131 (26%)
		ATP-synt_B	<198..278	CDD:304375	16/84 (19%)
		P4Hc	333..498	CDD:214780	59/172 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461764
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.850