DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and P4ha2

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	250/551 - (45%)
Similarity:	343/551 - (62%)	Gaps:	40/551 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LMLLLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREH 71
            ||...|:|..|    ..|.:|::..|.:|:..|..|:.:|:.||..:|.||:.:|:...:.:...
  Rat     9 LMSWFGVLSWV----QAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALT 69

  Fly    72 SDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLNGA 136
            |.::.|...|:::|:|||.|.|||.|||..:.:|:..|....|:.|::..|..  ||:|||.:||
  Rat    70 SKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQF--FPTDEDESGA 132

  Fly   137 AVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARM- 200
            |.||:||||||:||...::||:|.|.:|...:|.||||.:||.:|...|||||||||.:.:.::
  Rat   133 ARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLD 197

  Fly   201 -LEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
             .||.|     .||:.:|:||:::.::.|::..|:.:|..||.|.|.||||.||.|::|:.:.::
  Rat   198 AGEEAT-----VTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEE 257

  Fly   265 LQLRKMKGDDGTD----------EMPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLR 318
               |.....:.||          |.|...||            ||..||.||||| :|.:|...:
  Rat   258 ---RGKSLSNQTDAGLASQENLYERPVDYLP------------ERDVYESLCRGEGIKMTPRRQK 307

  Fly   319 SLRCRY-VTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTG 382
            .|.||| ..||||.|.:.|.|.|:....|:||.|:|.|.|.||:.||.:|:|:..||||::..||
  Rat   308 RLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTG 372

  Fly   383 ALETANYRISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKE 447
            .|..|:||:|||:||:..:|.|:..|.:|...:|||.:.:||.|||.|||:||.|||||||:|.:
  Rat   373 VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSD 437

  Fly   448 EQRAFEGLNLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHA 512
            |:.||:.|..|||:||.|.||||||.||||||..|..|::||||||.||.||.|.|:||.|||||
  Rat   438 ERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHA 502

  Fly   513 ACPVLTGTKWVSNKWIHERGQEFRRPCDLEE 543
            |||||.|.|||||||.|||||||.|||...|
  Rat   503 ACPVLVGCKWVSNKWFHERGQEFLRPCGTTE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	50/130 (38%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	103/172 (60%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	25/76 (33%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	103/172 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2869
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1311
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		otm44911
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840