Protein Alignment PH4alphaEFB and P4ha3

DIOPT Version :10

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_006508007.1
• Gene: P4ha3 / 320452
• MGIID: 2444049
• Length: 551
• Species: Mus musculus
• Alignment Length: 565
• Identity: 213/565 - (37%)
• Similarity: 297/565 - (52%)
• Gaps: 59/565 - (10%)

  Fly     8 MLLLGILLLVGGPA----NGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQ 68
            :.||.:|.|.|.||    ..:.::||..:...|..|..|:..|..|:|.:|.:|..|....|:..
Mouse     7 LALLALLALGGDPAAATGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDKVL 71

  Fly    69 REHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQ-YRSLLK-FPSDE 131
            ..|    .|:...|.||:.|:.|.|||.:|||.|.:.:|   .|:.::.:.. |..:.: .|:.|
Mouse    72 SLH----EDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLE---ATENIRALKDGYEKVEQDLPAFE 129

  Fly   132 DLNGAAVALLRLQDTYQLDTSSVARGKLNGIQYST-----------EMSSDDCFELGRQS----- 180
            ||.|||.||:||||.|.|:...:|||....:..|:           .:::||||::|:.|
Mouse   130 DLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKPSCGSRS 194

  Fly   181 ----YVNHDYYHTVLWMNEAMA--RMLEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNE 239
                |...||||.:.|:.||::  |............:..|.|:||||:.::.||:..||:::.|
Mouse   195 LQVAYDTGDYYHAIPWLEEAVSLFRRAHGEWKTEDEASLEDALDYLAFACFQVGNVSCALSLSRE 259

  Fly   240 LLQLLPHHERANGNKRFYEKEIAQQLQLRKMKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEM 304
            .|...|.::|...|...||:.:|:       .|.....|       .|...|.:..:..|..||.
Mouse   260 FLVYSPDNKRMARNVLKYERLLAE-------NGHQMAAE-------TAIQRPNVPHLQTRDTYEG 310

  Fly   305 LCR--GELKPSPSDLRSLRCRYVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMA 367
            ||:  |. :|:...:.||.|.|.||..|:|.|.|.:.|.||..|.|.:|||.:.|.|...|:.:|
Mouse   311 LCQTLGS-QPTHYQIPSLYCSYETNSSPYLLLQPARKEVVHLRPLIALYHDFVSDEEAQKIRELA 374

  Fly   368 RPRFRRATVQNSVTGALE-TANYRISKSAWLKTQEDRVIETVVQRTADMTGLDMDS--AEELQVV 429
            .|..:|:.|   .:|..: ...||||||||||...|.::.|:..|.|.:||||:..  ||.||||
Mouse   375 EPWLQRSVV---ASGEKQLQVEYRISKSAWLKDTVDPMLVTLDHRIAALTGLDIQPPYAEYLQVV 436

  Fly   430 NYGIGGHYEPHFDFARKEEQRAFEGLNLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAA 494
            |||||||||||||.|.......:. :..|||:||.:.|:|.||.||||.|...:.::...|..|.
Mouse   437 NYGIGGHYEPHFDHATSPSSPLYR-MKSGNRVATFMIYLSSVEAGGATAFIYGNFSVPVVKNAAL 500

  Fly   495 FWMNLHRDGQGDVRTRHAACPVLTGTKWVSNKWIHERGQEFRRPC 539
            ||.||||.|:||..|.||.||||.|.|||:||||||.||||||||
Mouse   501 FWWNLHRSGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..161	CDD:462433	47/134 (35%)
		P4Hc	356..529	CDD:214780	85/175 (49%)
P4ha3	XP_006508007.1	P4Ha_N	31..158	CDD:462433	47/133 (35%)
		P4Hc	363..535	CDD:214780	85/175 (49%)