DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and CG31524

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	170/533 - (31%)
Similarity:	258/533 - (48%)	Gaps:	66/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMD---EYQREHSDASHDITAYVSNPINAY 89
            ::..|::||..|..|::.||||    .:||::..|.:.   :..||..|.|....::  :..|.|
  Fly    31 SVVNMDDLLNMEDDLVSKLEGY----AEKLSYKANTIRWGIQQMREQLDKSKKEQSF--DLFNRY 89

  Fly    90 LLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSL--LKFPSDEDLNGAAVALLRLQDTYQLDTS 152
            ...:.:..||...:..::..|..|.|    .|:.:  |:.|.:.||..|:.|:.|:|.||.:.::
  Fly    90 SFIRHMQADWLMWKQYLDKPVIRDEL----NYKQMDNLRMPQELDLFDASEAIRRMQATYAMLSN 150

  Fly   153 SVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWM---NEAMAR--------MLEEPTN 206
            .:|.|.|:|:||::::|..||..:||.......:.....|:   .:|..|        :|..|
  Fly   151 DIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRKGPQTEMILLRGP-- 213

  Fly   207 HTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQLQLRK-- 269
                 |||::...|....::..|.|.||......|:..||           :.||.|:.|..|
  Fly   214 -----TKAELFRTLGKVRFERRNEEGALKAYQAALKHSPH-----------DLEIFQEYQNLKRR 262

  Fly   270 ---MKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEMLCRGELKPSPSDLRSLRCRYVTNRVPF 331
               :...:...|.|..|:...:..|.             |.|..: .|..|..|.|.|.....||
  Fly   263 VLTLSPSEPIREEPNDDIEEMELPPC-------------CSGRCE-GPRKLNRLYCVYNCVTAPF 313

  Fly   332 LRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYRISKSAW 396
            |||.|:|.|.:..||::::.||.:...|..||:..::.:...:...|: ....|.|.:|.|||.|
  Fly   314 LRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNA-ANEFEIAKFRTSKSVW 377

  Fly   397 LKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGLNLGNRI 461
            ..:..:.....:.||..:.|||||..:|..||:||||||.:|.|||.:..:|.|...|..  :|:
  Fly   378 FDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYI--DRL 440

  Fly   462 ATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNK 526
            ||.|||::||.|||||.|..|:..:|||.||...|.|||.:|...|||.|..|||:.|:|||.:|
  Fly   441 ATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSK 505

  Fly   527 WIHERGQEFRRPC 539
            ||.::||||||||
  Fly   506 WIDDKGQEFRRPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	36/135 (27%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	72/172 (42%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	36/135 (27%)
		TPR_11	215..>259	CDD:290150	14/54 (26%)
		TPR_2	216..249	CDD:285020	9/43 (21%)
		P4Hc	340..507	CDD:214780	71/169 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461819
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900