DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and CG32201

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	169/568 - (29%)
Similarity:	262/568 - (46%)	Gaps:	92/568 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LMLLLGILLL---VGGPANGEVYTALAEMEE-------------LLETESVLITNLEGYIRVQED 55
            |.:|||..:|   ||         .:.::||             ||:.|.....||...:....:
  Fly     8 LPVLLGFAVLNSFVG---------CVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGE 63

  Fly    56 KLNFLKNKMDEYQREHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQ 120
            |...|:..:.....|...:.::...||||||||:.|.:|...|..:.....:..:|..   |.:.
  Fly    64 KFEALRMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEG---NQSI 125

  Fly   121 YRSLLKF-PSDEDLNGAAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNH 184
            ...|:|. |:|.|:..|...:.|::..|.|....:|:|.|.|:||:.:::..|...:|...|...
  Fly   126 LVDLVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQS 190

  Fly   185 DYYHTVLWMNEAMARMLE-----------EPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTN 238
            ||.....|...|..|.||           :|:.|........:.:|.:.::....:||.|..|..
  Fly   191 DYQTAAKWYRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQ 255

  Fly   239 ELLQLLPHHERANGNKRFYEKEIAQQLQLRKMKGDDGTDEMPKSDLPVAKSDPAIFDMTE-RRA- 301
                                   |.|.:|..:..|  .:| |::|:.|.|      |:.: :|:
  Fly   256 -----------------------ASQEELDNIMSD--LNE-PQNDVEVEK------DLYQVKRSP 288

  Fly   302 --YEMLCRGELKPSPSDLRSLRCRYVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIK 364
              .|:.|||..:..    .:|.|||.:....||||.||||||:..||::.:||:.:|||||..:|
  Fly   289 SNCELGCRGLYRQK----TNLVCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELK 349

  Fly   365 RMARPRFRRATVQNSVTGALETANYRISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVV 429
            ..:.........|.:.|...:|.   :....|..|  ..|.|.:.||..||||.:....|:||:.
  Fly   350 GQSMNMVNGYASQRNGTEIRDTV---VRYDWWSNT--SLVRERINQRIIDMTGFNFLKDEKLQIA 409

  Fly   430 NYGIGGHYEPHFDFARKEEQRAFEGLN---LGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKG 491
            |||:|.:::||||::    ...||..|   ||:|:|::|||.|:|.|||||||..::..:||:||
  Fly   410 NYGLGTYFQPHFDYS----SDGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKG 470

  Fly   492 TAAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNKWIHERGQEFRRPC 539
            :..:|.|||.||:.|:|:.|:.||||.|.:|...||:....|.|..||
  Fly   471 SMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	34/144 (24%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	70/175 (40%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	32/131 (24%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	69/174 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461760
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900