Protein Alignment PH4alphaEFB and P4HA3

DIOPT Version :9

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 202/614 - (32%)
• Similarity: 286/614 - (46%)
• Gaps: 115/614 - (18%)

  Fly     6 RLMLLLGILLL-VGGP----ANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMD 65
            ||..||.:|.| .|.|    |.|:.::||..:...|..|..|:..|..|:|.:|.:|..|....|
Human     6 RLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD 70

  Fly    66 EYQREHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVG----TDFLQNITQYRSLLK 126
            :....|.|:    |..|:||:.|:.|.|||.:|||.|.:.:|....    .|..:.:.|     .
Human    71 KVLSLHEDS----TTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQ-----D 126

  Fly   127 FPSDEDLNGAAVALLRLQDTYQLDTSSVARGKLNGIQ-------YSTE----MSSDDCFELGRQS 180
            .|:.|||.|||.||:||||.|.|:...:|||....:.       ||.:    ::.||||::|:.:
Human   127 LPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVA 191

  Fly   181 YVNHDYYHTVLWMNEAMARML----EEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELL 241
            |...||||.:.|:.||::...    |..|....|.  .|.|::|||:.::.||:..||:::.|.|
Human   192 YDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASL--EDALDHLAFAYFRAGNVSCALSLSREFL 254

  Fly   242 QLLPHHERANGNKRFYEKEIAQQLQLRKMKGDDGTDEMPKSDLPVAK-SDPAIFDMTERRAYEML 305
            ...|.::|...|...||:.:|               |.|...:..|. ..|.|..:..|..||.|
Human   255 LYSPDNKRMARNVLKYERLLA---------------ESPNHVVAEAVIQRPNIPHLQTRDTYEGL 304

  Fly   306 CR--GELKPSPSDLRSLRCRYVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMAR 368
            |:  |. :|:...:.||.|.|.||...:|.|.|::.|.:|.:|||.:|||.:.|||...|:.:|.
Human   305 CQTLGS-QPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAE 368

  Fly   369 PRFRRATVQNSVTGALE-TANYRISKSAWLKTQEDRVIETVVQRTADMTGLDM--DSAEELQVVN 430
            |..:|:.|   .:|..: ...||||||||||...|..:.|:..|.|.:||||:  ..||.|||||
Human   369 PWLQRSVV---ASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVN 430

  Fly   431 YGIGGHYEPHFDFARKEEQRAFEGLNLGNRIATVLFYMSDVEQGGATVFTSLH------------ 483
            ||||||||||||.|.......:. :..|||:||.:.|:|.||.||||.|...:
Human   431 YGIGGHYEPHFDHATSPSSPLYR-MKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRHCFGG 494

  Fly   484 TALFPKKGTA--------AFW----------MNLHRDGQGDVRTRHAACPVLTGTKWVSNKW--- 527
            |.....|||.        ::|          |::.|:      :...|.|.|.........|
Human   495 TCTGVVKGTVTHFMLAVLSWWEISGWPTSGYMSMDRN------SADPAAPALKTELLAERSWWSP 553

  Fly   528 -IHERGQE--------------FRRPCDL 541
             ..:|.||              .||||.|
Human   554 VAFQRSQEPKAGVGEEKAEQPPGRRPCQL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	48/134 (36%)
		P4Hc	356..529	CDD:214780	72/209 (34%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	40/109 (37%)
		TPR_12	186..252	CDD:290160	21/67 (31%)
		P4Hc	356..>478	CDD:214780	60/125 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760