DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaEFB and phy-3

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_507251.2	Gene:	phy-3 / 188624	WormBaseID:	WBGene00004026	Length:	318	Species:	Caenorhabditis elegans

Alignment Length:	233	Identity:	61/233 - (26%)
Similarity:	107/233 - (45%)	Gaps:	11/233 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 LCRGELKPSPSDLRSLRC-RYVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMAR 368
            ||..|.|.:........| .||.|.:      |:.:|.:...|.:|||.:.|...:.........
Worm    56 LCDDETKDTKWQKNDSICITYVYNML------PVDMEIISWAPTLVIYRNLMSPRQTASFLNFIE 114

  Fly   369 PRFRRATVQNSVTGALETANYRISKSAWLKTQEDRV-IETVVQRTADMTGLDMDSAEELQVVNYG 432
            .|.......:....::|| .:|.:..:::..::..| :|..:|....:.||::..||....::|.
Worm   115 QRDLEIQKTSDFGTSIET-THRRANGSFIPPEDSNVTVEIKMQAQKRIPGLNLTVAEHFSALSYL 178

  Fly   433 IGGHYEPHFDFARKEEQRAFE-GLN-LGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAF 495
            .||||..|:|:.....::.:: .:| .||||.|::|.:...|:||.|||.|:.:.:....|.|.|
Worm   179 PGGHYAVHYDYLDYRSKQDYDWWMNKTGNRIGTLIFVLKPAEKGGGTVFPSIGSTVRANAGDAFF 243

  Fly   496 WMNLHRDGQGDVRTRHAACPVLTGTKWVSNKWIHERGQ 533
            |.|...|.:.::.:.|..||:..|.|.::..||....|
Worm   244 WFNAQADEEKEMLSNHGGCPIYEGRKVIATIWIRAYNQ 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	44/175 (25%)
phy-3	NP_507251.2	P4Hc	102..277	CDD:214780	44/175 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760