Protein Alignment PH4alphaEFB and P4ha2

DIOPT Version :10

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_006532515.1
• Gene: P4ha2 / 18452
• MGIID: 894286
• Length: 557
• Species: Mus musculus
• Alignment Length: 571
• Identity: 253/571 - (44%)
• Similarity: 345/571 - (60%)
• Gaps: 60/571 - (10%)

  Fly     7 LMLLLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREH 71
            ||...|:|..|    ..|.:|::..|.:|:..|..|:.:|:.||.|:|.||..:|:...:.:...
Mouse    11 LMSWFGVLSWV----QAEFFTSIGHMTDLIYAEKDLVQSLKEYILVEEAKLAKIKSWASKMEALT 71

  Fly    72 SDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLNGA 136
            |.::.|...|:::|:|||.|.|||.|||..:.:|:..|....|:.|::..|..  ||:|||.:||
Mouse    72 SRSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDASAGFVANLSVQRQF--FPTDEDESGA 134

  Fly   137 AVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARM- 200
            |.||:||||||:||..:::||:|.|.:|...:|.||||.|||.:|...|||||||||.:.:.::
Mouse   135 ARALMRLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGRSAYNEGDYYHTVLWMEQVLKQLD 199

  Fly   201 -LEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
             .||.|     .||:.:|:||:::.::.|::..|:.:|..||.|.|.||||.||.|::|:.:.::
Mouse   200 AGEEAT-----VTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEE 259

  Fly   265 LQLRKMKGDDGTD----------EMPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLR 318
               |.....:.||          |.|...||            ||..||.||||| :|.:|...:
Mouse   260 ---RGKSLSNQTDAGLATQENLYERPTDYLP------------ERDVYESLCRGEGVKLTPRRQK 309

  Fly   319 SLRCRY-VTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTG 382
            .|.||| ..||||.|.:.|.|.|:....|:||.|:|.|.|.||:.||.:|:|:..||||::..||
Mouse   310 KLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTG 374

  Fly   383 ALETANYRISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARK- 446
            .|..|:||:|||:||:..:|.|:..|.:|...:|||.:.:||.|||.|||:||.|||||||:|:
Mouse   375 VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRRP 439

  Fly   447 -------------------EEQRAFEGLNLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGT 492
                               :||.||:.|..|||:||.|.||||||.||||||..|..|::|||||
Mouse   440 FDSGLKTEGNRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGT 504

  Fly   493 AAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNKWIHERGQEFRRPCDLEE 543
            |.||.||.|.|:||.||||||||||.|.|||||||.|||||||.|||...|
Mouse   505 AVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGTTE 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..161	CDD:462433	52/132 (39%)
		P4Hc	356..529	CDD:214780	104/192 (54%)
P4ha2	XP_006532515.1	P4Ha_N	28..159	CDD:462433	52/132 (39%)
		P4Hc	348..541	CDD:214780	104/192 (54%)