Protein Alignment PH4alphaEFB and P4ha1

DIOPT Version :10

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_035160.1
• Gene: P4ha1 / 18451
• MGIID: 97463
• Length: 534
• Species: Mus musculus
• Alignment Length: 543
• Identity: 261/543 - (48%)
• Similarity: 364/543 - (67%)
• Gaps: 17/543 - (3%)

  Fly     5 WRLMLLLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQR 69
            |  ::|:..:||....|:...:|::.:|.:|:..|..|:|:|:.||:.:||||..:|...::..|
Mouse     3 W--VVLMMAILLPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 EHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLN 134
            ..|.|:.|...:|.:|:||:.|.|||.|:|.::|||:..|:...|:.|:|..|..  ||:|||..
Mouse    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQY--FPNDEDQV 128

  Fly   135 GAAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMAR 199
            |||.||.||||||.|||:::::|.|.|:|:.:.::::||||||:.:|...|||||.|||.:|:.:
Mouse   129 GAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALTQ 193

  Fly   200 MLEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
             |||  ....:..|..:|:||:::.|::|:::.||.:|.:||:|.|.|:|||||..::|..::::
Mouse   194 -LEE--GELSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKE 255

  Fly   265 LQLRKMKGDDGTDE--MPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYVT 326
            ....|....|.:|:  .||      |...|:..:.||:.|||||||| :|.:|...:.|.|||..
Mouse   256 KDANKSASGDQSDQKTAPK------KKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHD 314

  Fly   327 -NRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYR 390
             ||.|...|.|.|.|:....|.|:.:||.:.|:||:::|.:|:||.||||:.|.|||||||.:||
Mouse   315 GNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPVTGALETVHYR 379

  Fly   391 ISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGL 455
            |||||||...||.|:..:..|..|:||||:.:||||||.|||:||.||||||||||:|..||..|
Mouse   380 ISKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFREL 444

  Fly   456 NLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGT 520
            ..||||||.|||||||..||||||..:..:::||||||.||.||...|:||..|||||||||.|.
Mouse   445 GTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGN 509

  Fly   521 KWVSNKWIHERGQEFRRPCDLEE 543
            |||||||:|||||||||||.|.|
Mouse   510 KWVSNKWLHERGQEFRRPCTLSE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..161	CDD:462433	56/132 (42%)
		P4Hc	356..529	CDD:214780	111/172 (65%)
P4ha1	NP_035160.1	P4Ha_N	24..155	CDD:462433	56/132 (42%)
		TPR	205..238		12/32 (38%)
		P4Hc	345..518	CDD:214780	111/172 (65%)