Protein Alignment PH4alphaEFB and P4ha1

DIOPT Version :9

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001303300.1
• Gene: P4ha1 / 18451
• MGIID: 97463
• Length: 534
• Species: Mus musculus
• Alignment Length: 543
• Identity: 257/543 - (47%)
• Similarity: 360/543 - (66%)
• Gaps: 17/543 - (3%)

  Fly     5 WRLMLLLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQR 69
            |  ::|:..:||....|:...:|::.:|.:|:..|..|:|:|:.||:.:||||..:|...::..|
Mouse     3 W--VVLMMAILLPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 EHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLN 134
            ..|.|:.|...:|.:|:||:.|.|||.|:|.::|||:..|:...|:.|:|..|..  ||:|||..
Mouse    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQY--FPNDEDQV 128

  Fly   135 GAAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMAR 199
            |||.||.||||||.|||:::::|.|.|:|:.:.::::||||||:.:|...|||||.|||.:|:.:
Mouse   129 GAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALTQ 193

  Fly   200 MLEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
             |||  ....:..|..:|:||:::.|::|:::.||.:|.:||:|.|.|:|||||..::|..::::
Mouse   194 -LEE--GELSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKE 255

  Fly   265 LQLRKMKGDDGTDE--MPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYVT 326
            ....|....|.:|:  .||      |...|:..:.||:.|||||||| :|.:|...:.|.|||..
Mouse   256 KDANKSASGDQSDQKTAPK------KKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHD 314

  Fly   327 -NRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYR 390
             ||.|...|.|.|.|:....|.|:.:||.:.|:||:::|.:|:||..||||.:..||.|.||.||
Mouse   315 GNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYR 379

  Fly   391 ISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGL 455
            :||||||...||.|:..:..|..|:||||:.:||||||.|||:||.||||||||||:|..||..|
Mouse   380 VSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFREL 444

  Fly   456 NLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGT 520
            ..||||||.|||||||..||||||..:..:::||||||.||.||...|:||..|||||||||.|.
Mouse   445 GTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGN 509

  Fly   521 KWVSNKWIHERGQEFRRPCDLEE 543
            |||||||:|||||||||||.|.|
Mouse   510 KWVSNKWLHERGQEFRRPCTLSE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	55/130 (42%)
		P4Hc	356..529	CDD:214780	107/172 (62%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	55/130 (42%)
		TPR	205..238		12/32 (38%)
		P4Hc	345..518	CDD:214780	107/172 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2702
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30998
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1297
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		otm42846
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	LDO	PTHR10869
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2705
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820