DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and phy-2

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_502317.1	Gene:	phy-2 / 178170	WormBaseID:	WBGene00004025	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	268/537 - (49%)
Similarity:	364/537 - (67%)	Gaps:	24/537 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREHSDASHD 77
            ::.|:.|.|:.:::||:|:::.:|..|..:.|.::.||..:..:|:.|:....||...::.|...
Worm     6 LVCLLAGLAHADLFTAIADLQHMLGAEKDVTTIIDQYIEAERARLDDLRRYAHEYVHRNAHAESV 70

  Fly    78 ITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNIT--QYRSLLKFPSDEDLNGAAVAL 140
            ...:|:||||||||.|||||:|::|||:|.::..:.||:|||  :.||.:|||.:|||:|||.||
Worm    71 GPEFVTNPINAYLLIKRLTTEWKKVENIMLNNKASTFLKNITDNRVRSEVKFPGEEDLSGAATAL 135

  Fly   141 LRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARMLEE-- 203
            |||||||.|||..::.|.:.|.:.|.::|..|.||:||.:|...||||.::||..|:.::..|
Worm   136 LRLQDTYSLDTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMWMQVALVKIENENP 200

  Fly   204 PTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQLQLR 268
            ||     ..:.:||||||:|.|::||:..||::|..|.::.|:|.||.||.::||    ..||.:
Worm   201 PT-----IEEWEILEYLAYSLYQQGNVRRALSLTKRLAKIAPNHPRAKGNVKWYE----DMLQGK 256

  Fly   269 KMKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEMLCRGELKP-SPSDLRSLRCRYVTNRVPFL 332
            .|.||     :|    |:.........:.||.|||.|||||:.| .|.....||| |:....|||
Worm   257 DMVGD-----LP----PIVNKRVEYDGIVERDAYEALCRGEIPPVEPKWKNKLRC-YLKRDKPFL 311

  Fly   333 RLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYRISKSAWL 397
            :|.|:|:|.:..||..|::.:.::||||::||.:|.|:.:|||||||.||.||.|.|||||||||
Worm   312 KLAPIKVEILRFDPLAVLFKNVIHDSEIEVIKELASPKLKRATVQNSKTGELEHATYRISKSAWL 376

  Fly   398 KTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGLNLGNRIA 462
            |...|.||:.|.:|..|.|.|:..::|||||.|||:||||:||||||||||:.||:.||.|||||
Worm   377 KGDLDPVIDRVNRRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKTLNTGNRIA 441

  Fly   463 TVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNKW 527
            |||||||..|:||||||..|.||:||.|..|.||.||.|||:||:||||||||||.|.|||||||
Worm   442 TVLFYMSQPERGGATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGVKWVSNKW 506

  Fly   528 IHERGQEFRRPCDLEED 544
            |||:||||.|||.|||:
Worm   507 IHEKGQEFTRPCGLEEE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	60/132 (45%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	117/172 (68%)
phy-2	NP_502317.1	P4Ha_N	21..154	CDD:285528	60/132 (45%)
		TPR_16	169..240	CDD:290168	30/75 (40%)
		P4Hc	335..508	CDD:214780	117/172 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I1733
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30998
Inparanoid	1	1.050	517	1.000	Inparanoid score	I693
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		otm14484
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2705
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860