Protein Alignment PH4alphaEFB and p4ha1

DIOPT Version :10

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_031761963.1
• Gene: p4ha1 / 100490484
• XenbaseID: XB-GENE-987760
• Length: 526
• Species: Xenopus tropicalis
• Alignment Length: 544
• Identity: 257/544 - (47%)
• Similarity: 345/544 - (63%)
• Gaps: 38/544 - (6%)

  Fly    10 LLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREHSDA 74
            |||:.    ..|:.:.:|::..|.:||.||..|:|:|:.||:.:|.||..:|...|:.......|
 Frog     9 LLGLF----SCAHADFFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTA 69

  Fly    75 SHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLNGAAVA 139
            :.|...|:.:|:||:.|.|||.|:|.::|||:..|:...|:.|:|..|..  ||:|||..|||.|
 Frog    70 TKDPEGYLGHPVNAFKLMKRLNTEWVKLENLILKDISDGFISNLTIQRQY--FPNDEDQTGAAKA 132

  Fly   140 LLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARMLEEP 204
            ||||||||.|||.::::|.|.|:::.|.::::|||:||:.:|.:.|||||.|||.:|::::   .
 Frog   133 LLRLQDTYNLDTDTISKGNLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQL---D 194

  Fly   205 TNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKR-FYEKEI------- 261
            .....|..|..:|:||:::.|::|:::.|||:|...|:|.|.|:|.|||.| ...||.
 Frog   195 AGEESSLDKVMVLDYLSYAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSP 259

  Fly   262 AQQLQLRKMKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYV 325
            ::..:||..||      .||             |..|:..||.||||| :|.:....:.|.|||.
 Frog   260 SEGAELRTRKG------RPK-------------DHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYF 305

  Fly   326 TNRV-PFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANY 389
            ..:. |.|.|.|.|.|:....|.||.|||.:.|.||..:|.:|:||.||||:.|.:||.||||.|
 Frog   306 DGKKDPLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRATISNPITGVLETAQY 370

  Fly   390 RISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEG 454
            ||:|||||...||.|:..:.:|...:|||||.:||||||.||||||.|||||||.||.|..||:.
 Frog   371 RITKSAWLSGYEDPVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKK 435

  Fly   455 LNLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTG 519
            |..|||:||.||||||||.||||||..:..|::||||||.||.||...|:||..|||||||||.|
 Frog   436 LGTGNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVG 500

  Fly   520 TKWVSNKWIHERGQEFRRPCDLEE 543
            .|||||||||||||||||||:|.|
 Frog   501 NKWVSNKWIHERGQEFRRPCNLSE 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..161	CDD:462433	57/132 (43%)
		P4Hc	356..529	CDD:214780	110/172 (64%)
p4ha1	XP_031761963.1	P4Ha_N	23..154	CDD:462433	57/132 (43%)
		NrfG	181..>244	CDD:443378	24/65 (37%)
		P4Hc	337..510	CDD:214780	110/172 (64%)