Protein Alignment CDase and ASAH2B

DIOPT Version :9

• Sequence 1: NP_001263109.1
• Gene: CDase / 43618
• FlyBaseID: FBgn0039774
• Length: 704
• Species: Drosophila melanogaster
• Sequence 2: NP_001072984.1
• Gene: ASAH2B / 653308
• HGNCID: 23456
• Length: 165
• Species: Homo sapiens
• Alignment Length: 189
• Identity: 54/189 - (28%)
• Similarity: 82/189 - (43%)
• Gaps: 48/189 - (25%)

  Fly   528 FGPHTHSIYMDVF---ERLTKAMMRNETVDAGPSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKS 589
            |...||  |:..|   |.|.:.::|  .||..|......||:
Human     7 FMDRTH--YLLTFSSSETLLRLLLR--IVDRAPKGRTFGDVL----------------------- 44

  Fly   590 QPNK-EYGINETVKVTYISGNPRNNL--FTEKTYFTIER-KINEDRWKVAYTDASWETKMVWHRT 650
            ||.| ||.:.|..:|.::..||:|::  .|.:|:.|:|: :.....|::...||||||:..||:
Human    45 QPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHK- 108

  Fly   651 NTILGFSEMDIYWDISPQTLPGEYRIRHSGEYK--------YILGGKYPYEGLTHSFTV 701
             .:||.|...:.|.|.....||.||||:.|..:        .||.    :||.:.:|.|
Human   109 -GLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILS----FEGTSPAFEV 162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDase	NP_001263109.1	PTZ00487	24..701	CDD:240437	53/187 (28%)
		Ceramidase_alk	25..538	CDD:282576	4/9 (44%)
		Ceramidse_alk_C	540..701	CDD:293653	49/175 (28%)
ASAH2B	NP_001072984.1	Ceramidse_alk_C	<30..162	CDD:407221	45/160 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141661
Domainoid	1	1.000	84	1.000	Domainoid score	I8254
eggNOG	1	0.900	-	-		E1_KOG2232
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118111at33208
OrthoFinder	1	1.000	-	-		FOG0003346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750