DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2224 and MPND

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001287791.1	Gene:	MPND / 84954	HGNCID:	25934	Length:	501	Species:	Homo sapiens

Alignment Length:	251	Identity:	56/251 - (22%)
Similarity:	88/251 - (35%)	Gaps:	72/251 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 TGANRSLPGSG----LLLPAASE------AAADKT------TNSKPSFDRNQKPSYNRTDS---- 241
            |.|:.|....|    ||:....|      :|.||:      :.|:|:......|. .|.||
Human   173 TAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPG-KRVDSKIRV 236

  Fly   242 ----LLAGSLRLVYVPGDTMEVFLKLALAN--------TSKNI-------------ETCGVLAGH 281
                .:.||..|...|...:|| ...|..|        .|.|:             |..|.|.|.
Human   237 PVRYCMLGSRDLARNPHTLVEV-TSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGR 300

  Fly   282 LSQNQLYITHIIT---PQQQGTPDSCNTMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLH 343
            ...|...:|.:..   ..:.|..::...: ||:|:.......|..:||.|:||...|..|..|:.
Human   301 WDVNSQMLTVLRAFPCRSRLGDAETAAAI-EEEIYQSLFLRGLSLVGWYHSHPHSPALPSLQDID 364

  Fly   344 THCSYQIMM-------PEALAIVCAPKYN--------TTGFFILTP------HYGL 378
            ....||:.:       ...||::|:|.|:        .:.|:::.|      .||:
Human   365 AQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	38/177 (21%)
MPND	NP_001287791.1	MPN_2A_DUB	266..450	CDD:163698	32/156 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900