DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and stambpa

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_956792.1	Gene:	stambpa / 797422	ZFINID:	ZDB-GENE-040426-1551	Length:	418	Species:	Danio rerio

Alignment Length:	428	Identity:	186/428 - (43%)
Similarity:	271/428 - (63%)	Gaps:	39/428 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            |..::|::.|:..|:.::|.:::|..||:|||.|::||||:|..|||.|:|||||.:|:||||||
Zfish     9 VSSEDRVRALTKLGSSVDVSEDVPPRRYFRSGMEIIRMANIYADEGNVEHAFILYNKYITLFIEK 73

  Fly    78 IRQHPDYGSVK-AEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAE---RVKELER 138
            :.:|.:|.:.. .|.::..||:|:...|..|:|:..||..|.:|:.::|..|.||   |..|:.:
Zfish    74 LPKHREYKTANIPEKKETMRKLKEIAFPKAEELKKLLLKQYDKEHAEYLVRKRAEDAARAVEMLK 138

  Fly   139 ERERERERQR-----QKEREKAGSSAIPSLI-----PANLHVLIDEGN---QPSAPDLGLLDQVV 190
            ::|:|.:|||     |::||:...||...:|     ......::.|.:   .|:|||:.|.|  |
Zfish   139 QQEQEAQRQRLAELHQRQREQEQFSAFEEMIRRQELEKERRRIVQEFSIPVSPTAPDVLLPD--V 201

  Fly   191 YPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSK--PSFDRNQKPS--YNRTDSLLAGSLRLVY 251
            :.           |....|.|....|.|   ||.:  |:|||:.|||  .:...|.|...||.::
Zfish   202 HG-----------PPQASLSPQTPPAGA---TNHQGLPAFDRSLKPSVPVSAGHSALVNGLRQLF 252

  Fly   252 VPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQIFDVQ 316
            ||.:..:.|||||..||::.:||||:|.|.|.:|...:||:|.|:|.|.||.|:|.:||::|.:|
Zfish   253 VPAELCQRFLKLAETNTARAVETCGILCGKLMKNAFTVTHVIVPKQCGGPDYCDTENEEELFLIQ 317

  Fly   317 DQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYGLDYI 381
            ||..|||||||||||||||||||||||||||||:|:||::||||:||:|.||:|.|| .||:|.:
Zfish   318 DQNDLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFNETGYFRLT-DYGMDDV 381

  Fly   382 AQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ..|:|.||||||.|||||..:.|:.: ....:.::|||
Zfish   382 GTCKQRGFHPHPKDPPLFAASHHVSI-TDGSVTMLDLR 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	44/103 (43%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	97/171 (57%)
stambpa	NP_956792.1	USP8_dimer	13..114	CDD:286108	43/100 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..218		6/31 (19%)
		MPN_AMSH_like	248..418	CDD:163697	97/171 (57%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	329..342		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580343
Domainoid	1	1.000	146	1.000	Domainoid score	I4486
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2330
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm24716
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1402
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800