DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and Stambp

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001349007.1	Gene:	Stambp / 70527	MGIID:	1917777	Length:	424	Species:	Mus musculus

Alignment Length:	443	Identity:	191/443 - (43%)
Similarity:	265/443 - (59%)	Gaps:	57/443 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GDVE--PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73
            |||.  ||:|::.||..|:.:|:::::|..||||||.|::|||:||..|||.|:|||||.:|:||
Mouse     5 GDVSLPPQDRVRILSQLGSAVELNEDIPPRRYYRSGVEIIRMASVYSEEGNIEHAFILYNKYITL 69

  Fly    74 FIEKIRQHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKELE 137
            ||||:.:|.||.| :..|.:|..:|:|....|..|:|:.:||..|.:||||:...|:.|. :||.
Mouse    70 FIEKLPKHRDYKSAIIPEKKDAVKKLKSVAFPKAEELKTELLRRYTKEYEQYKERKKKEE-EELA 133

  Fly   138 R------ERERERER---QRQKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGLLDQVVYPN 193
            |      |.|:|::|   |:||:.|:....|...:|...   .:::.......:.|.:|
Mouse   134 RNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEEMIQRQ---ELEKERLKIVQEFGKVD------ 189

  Fly   194 DFPTGANRSLPG-SGLLLPAASEAAADKTTNS------------------KPSFDRNQKP---SY 236
                      || .|.|||...:...|...:|                  .|..||:.||   |.
Mouse   190 ----------PGPCGPLLPDLEKPCVDVAPSSPFSPTQTPDCNTGMRPAKPPVVDRSLKPGALSV 244

  Fly   237 NRTDSLLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTP 301
            ......:.| ||.:.||.:....||:||.|||:|.|||||||.|.|.:|:..|||::.|:|.|.|
Mouse   245 IENVPTIEG-LRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGP 308

  Fly   302 DSCNTMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNT 366
            |.|:|.:||:||.:||.:.|:|||||||||||||||||||||||||||:|:||::||||:||:..
Mouse   309 DYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQE 373

  Fly   367 TGFFILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            ||||.|| .|||..|:.|||.|||||..|||||.:..|:.:.::. :.:.|||
Mouse   374 TGFFKLT-DYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRI-VTITDLR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	49/103 (48%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
Stambp	NP_001349007.1	Interaction with CHMP3. /evidence=ECO:0000250	1..127		58/121 (48%)
		USP8_dimer	8..114	CDD:370218	49/105 (47%)
		Interaction with STAM1. /evidence=ECO:0000250	227..231		0/3 (0%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836833
Domainoid	1	1.000	147	1.000	Domainoid score	I4492
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2459
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm43492
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1402
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790