DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and stambpb

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001032659.1	Gene:	stambpb / 641572	ZFINID:	ZDB-GENE-051127-31	Length:	418	Species:	Danio rerio

Alignment Length:	438	Identity:	192/438 - (43%)
Similarity:	273/438 - (62%)	Gaps:	59/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEK 77
            :.|:||::.|:..|..:|:::::|:.||:|||.||:|||:||..|||.|:||:||.:|:||||||
Zfish     9 LSPEERVRALTKKGGAVEMNESVPLRRYFRSGMEMIRMAHVYAEEGNTEHAFVLYNKYITLFIEK 73

  Fly    78 IRQHPDYG-SVKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASK--EAERV-KELER 138
            :.:||:|. |...|.::|.||:||...|..|:|:..||..|:||:..:::.|  |||.| :||.|
Zfish    74 LPKHPEYKLSNIPEKKEILRKLKDTAFPQAEQLKKLLLRRYEREHADYISKKRVEAEAVERELSR 138

  Fly   139 ERERERERQR-----QKEREKAGSSAIPSLI--------PANLHVLIDEGNQPSAP--DLGLLDQ 188
            :||.:.||:|     ::::|:...|....:|        |...|.       |:||  |..|:..
Zfish   139 QRELDAERRRVAELQRRQQEQEQFSIFEEMIQQRERHRHPHTHHT-------PAAPQTDTPLIPG 196

  Fly   189 VVYP----NDFPT--------GANRSLPGSGLLLPAASEAAADKTTNSKPSFDRNQKPSYNRTDS 241
            :..|    .:.||        .||.|.|.:    ||            .|:|||:.|||:..|
Zfish   197 IQGPPVPFPESPTPPQSPQQPSANHSTPSA----PA------------PPTFDRSLKPSHLTT-- 243

  Fly   242 LLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNT 306
             |...||.:.||.:....||:||..||.:.:||||:|.|.|::|...:||::.|:|.|.||.|:|
Zfish   244 -LIDGLRQIAVPAELCGKFLRLANNNTIRAVETCGILCGTLNRNAFTVTHVVVPKQCGGPDYCDT 307

  Fly   307 MHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFI 371
            .:||::|.||||..|||||||||||||||||||||||||||||:|:||::||||:||:|.||:|.
Zfish   308 ENEEELFLVQDQYNLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFNQTGYFR 372

  Fly   372 LTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            || .||::.|:.|.|.||||||.|||||....|| :..:..:.::|||
Zfish   373 LT-DYGMEEISTCAQKGFHPHPKDPPLFTGGSHI-IITEDTVSMLDLR 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	49/103 (48%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	97/171 (57%)
stambpb	NP_001032659.1	USP8_dimer	13..116	CDD:286108	49/102 (48%)
stambpb	NP_001032659.1	MPN_AMSH_like	248..418	CDD:163697	97/171 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580344
Domainoid	1	1.000	146	1.000	Domainoid score	I4486
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2330
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm24716
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	O	PTHR12947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770