DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and mpnd

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001070033.1	Gene:	mpnd / 559169	ZFINID:	ZDB-GENE-060929-1162	Length:	458	Species:	Danio rerio

Alignment Length:	339	Identity:	68/339 - (20%)
Similarity:	119/339 - (35%)	Gaps:	106/339 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 KLRAKLLTHYQREY-EQFLASKEAERVKELERERERERERQRQKEREKAGSSAIPSLIPANLHVL 171
            :.|.:.|..|:..: .::..|.:...:.|.|       :.:...:.|:.|.:.||
Zfish   120 RYRGQKLVQYKTTWLHKYQPSADMSLISEGE-------DDEMGDDDEEEGKTTIP---------- 167

  Fly   172 IDEGNQPSAPDL---GLL---DQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTT----NSKP 226
            :::.|:.|.|:|   ||.   |:...|..:.|...|             :||.|..|    ::..
Zfish   168 VEDKNKKSKPELHEIGLTQRRDRERIPVRYCTLGTR-------------DAARDPHTLVELSAFS 219

  Fly   227 SFDRNQKPSYNRTDSLLAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITH 291
            :.:|.|..:...:.::|.           .|:....|    ||.  |..|.|.|....|...:|.
Zfish   220 AINRFQPFNVAVSSNVLL-----------LMDFHCHL----TSS--EVVGYLGGRWDTNTQLLTV 267

  Fly   292 IITPQQQGTPDSCNT---------MHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCS 347
            :     :..|  |.|         ..||:|........|..:||.|:||...|..|..|:.:...
Zfish   268 L-----RAFP--CRTRLADKDAAPAVEEEICQNLFMRGLSLVGWYHSHPRGPALPSLQDIDSQMD 325

  Fly   348 YQIMM-------PEALAIVCAPKYN--------TTGFFILTPHYGLDYIAQCRQSGFHPHPNDP- 396
            :|:.:       ...|.|:|.|.|:        .|.|:::.|.              ...|||.
Zfish   326 HQLRLQGSSNGFQPCLGIICGPYYHGNQGVASTITPFWVVPPP--------------EQRPNDHG 376

  Fly   397 -PLFMEAQHIRMDN 409
             |:.:|..::: ||
Zfish   377 IPVAVEVTYVQ-DN 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	3/10 (30%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	41/189 (22%)
mpnd	NP_001070033.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..175		7/44 (16%)
		MPN_2A_DUB	223..407	CDD:163698	44/206 (21%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	306..319		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900