DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and sst2

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001342969.1	Gene:	sst2 / 2542606	PomBaseID:	SPAC19B12.10	Length:	435	Species:	Schizosaccharomyces pombe

Alignment Length:	452	Identity:	161/452 - (35%)
Similarity:	239/452 - (52%)	Gaps:	59/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NMSMGDVEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYM 71
            |:..|...|....:..|..| ..:.:||:|:..:.|:.|.:.:.|:||:.|.::.|...|..||.
pombe     2 NILQGSEAPLSYEEIASRAG-AFDFNKNIPLKNWLRTSTTISKQAHVYVSEHDYSNGVFLLFRYC 65

  Fly    72 TLFIEKIRQHPDYGSVKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQRE-YEQFLASK-EAERVK 134
            .||: |.::|||..:.|.|:.|..:.:::.:    |::  :|:....:| |||:...| :.:.:|
pombe    66 ELFM-KCQKHPDAAAYKKELFDYYQGVRNAL----EEI--ELIKPIVKEQYEQYQCQKNDLDDLK 123

  Fly   135 ELERERERERERQRQKER----------EKAGSSAIPSLIPANLHVLIDEGNQ--PSAPDLGLLD 187
            :|..     ::.|...|:          |:...|.:..|.|::..:|..:..:  .|:.||...|
pombe   124 KLSM-----KDSQPSLEKPVSYVDEPILEQWALSDLQILPPSSTDLLSPDSQKLSKSSSDLPQFD 183

  Fly   188 QVVYP--NDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPSFDRN-----QKPSYNRTDS---L 242
               ||  |..|| .|.:||.|.......| .:..|..:.:|..|..     :||.|.||..   .
pombe   184 ---YPSLNSSPT-FNSNLPISSSRFEKTS-LSDSKLVSPEPLDDNKDIQFIKKPIYTRTSEPRPK 243

  Fly   243 LAGS------------LRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITP 295
            .||:            ||.:|:|....:|||.:...||.||:||||:|.|.|.||..:|||::.|
pombe   244 PAGTFKIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLETCGILCGKLRQNAFFITHLVIP 308

  Fly   296 QQQGTPDSCNTMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVC 360
            .|:.|.|:|.|..|..:|:.||:..|:||||||||||||.|:||||||||||||:|:|||:|||.
pombe   309 LQEATSDTCGTTDEASLFEFQDKHNLLTLGWIHTHPTQTCFMSSVDLHTHCSYQLMLPEAIAIVM 373

  Fly   361 APKYNTTGFFILTPHYGLDYIAQCRQSG-FHPHPNDPPLFMEAQ--HIRMDNQAKIKVIDLR 419
            ||..||:|.|.|....||..|.:||:.| |||| ......|.||  |:|..| :|::|:|||
pombe   374 APSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPH-EGKVYTMVAQPGHVREIN-SKLQVVDLR 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	26/102 (25%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	92/174 (53%)
sst2	NP_001342969.1	USP8_dimer	<26..111	CDD:312504	26/91 (29%)
sst2	NP_001342969.1	MPN_AMSH_like	260..433	CDD:163697	92/174 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	141	1.000	Domainoid score	I1209
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I891
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		oto101349
orthoMCL	1	0.900	-	-		OOG6_103166
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1402
SonicParanoid	1	1.000	-	-		X1584
TreeFam	1	0.960	-	-
	12	11.850