DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2224 and MYSM1

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001078956.1	Gene:	MYSM1 / 114803	HGNCID:	29401	Length:	828	Species:	Homo sapiens

Alignment Length:	502	Identity:	103/502 - (20%)
Similarity:	169/502 - (33%)	Gaps:	180/502 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTLFIEKIR 79
            |..:| |.::.|..|..|....:  :.:|....|:         |.:....|....:||:.|| :
Human   250 PNSKM-HETNQGEFITSDSQEAL--FSKSSRGCLQ---------NEKQDETLSSSEITLWTEK-Q 301

  Fly    80 QHPDYGSVKAEVRDINRKIKD-------------EIMPTTEKLRA-------KLLTHYQREYEQF 124
            .:.|..|::...:..|..||:             ..:|:.|....       ::|.|..:..|:
Human   302 SNGDKKSIELNDQKFNELIKNCNKHDGRGIIVDARQLPSPEPCEIQKNLNDNEMLFHSCQMVEE- 365

  Fly   125 LASKEAERVKELERERERERERQRQKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGL---- 185
              |.|.|.:|..|:|.|.:|...:::|::     |||...         ||.|...|:..|
Human   366 --SHEEEELKPPEQEIEIDRNIIQEEEKQ-----AIPEFF---------EGRQAKTPERYLKIRN 414

  Fly   186 --LDQVVYPNDFPTGANRSLPGSGL-----------------LLPAASEAAADKTTNSKPSFDRN 231
              |||  :....|...|::....||                 |:.|.:........|...:.|:.
Human   415 YILDQ--WEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQTVDKV 477

  Fly   232 QKPSYNRTDSLLAGSL-----------RLVYVP-GDTMEVFLKLALANTSKNIETCGVLAGHLSQ 284
            :  ..:|.|::.|..|           |.|..| |:..:          :|::|  |....|||.
Human   478 R--IRDRKDAVEAYQLAQRLQSMRTRRRRVRDPWGNWCD----------AKDLE--GQTFEHLSA 528

  Fly   285 NQLYITHIITPQQQGTPDS-------------------CNTMHEEQIFDVQDQMQLITLGWIHTH 330
            .:|....   .:::|.|..                   ||...||:    |:..|:
Human   529 EELAKRR---EEEKGRPVKSLKVPRPTKSSFDPFQLIPCNFFSEEK----QEPFQV--------- 577

  Fly   331 PTQTAFLSSVDLHTHCSYQIMMPEALAI-------------VCAPK---YNTTGFFILTPHYGLD 379
            ...:..|..:|||.|.|    |.|.:.:             |||.:   ..:||.     ...:|
Human   578 KVASEALLIMDLHAHVS----MAEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGL-----QCEMD 633

  Fly   380 YIAQCRQS------GF------HPHPN-DP-PLFMEAQHIRMDNQAK 412
            .::|.:.|      ||      |.||. || |...:     :|.|||
Human   634 PVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRD-----IDTQAK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	22/122 (18%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	48/227 (21%)
MYSM1	NP_001078956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		SANT	120..164	CDD:197842
		Myb_DNA-binding	120..162	CDD:278669
		SWIRM	382..461	CDD:282311	19/94 (20%)
		MPN_2A_DUB	571..753	CDD:163698	30/132 (23%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	656..669		6/12 (50%)
		LXXLL motif	774..778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810