Protein Alignment CG2224 and STAMBP

DIOPT Version :10

• Sequence 1: NP_651796.1
• Gene: CG2224 / 43617
• FlyBaseID: FBgn0039773
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_006454.1
• Gene: STAMBP / 10617
• HGNCID: 16950
• Length: 424
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 190/439 - (43%)
• Similarity: 273/439 - (62%)
• Gaps: 49/439 - (11%)

  Fly    11 GDVE--PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73
            |||.  |::|::.||..|:.:||::::|..||:|||.|::|||::|..|||.|:|||||.:|:||
Human     5 GDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITL 69

  Fly    74 FIEKIRQHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQF--LASKEAERV-- 133
            ||||:.:|.||.| |..|.:|..:|:|:...|..|:|:|:||..|.:||.::  ...||||.:
Human    70 FIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELAR 134

  Fly   134 -----KELERERERERERQRQKEREKAGSSAIPSLI------PANLHVL-----IDEG-NQPSAP 181
                 :|||:|::|..: |:|::.|:....|...:|      ...|.::     :|.| ..|..|
Human   135 NMAIQQELEKEKQRVAQ-QKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVP 198

  Fly   182 DLGLLDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPS----FDRNQKP-SYNRTDS 241
            ||......|:|.                |..:|...:|..|..:|:    .||:.|| :.:.::|
Human   199 DLEKPSLDVFPT----------------LTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSES 247

  Fly   242 L-LAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCN 305
            : ....||.|.|||.....||:||.|||::.:||||:|.|.|.:|:..|||::.|:|....|.||
Human   248 IPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCN 312

  Fly   306 TMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFF 370
            |.:||::|.:|||..|||||||||||||||||||||||||||||:|:||::||||:||:..||||
Human   313 TENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFF 377

  Fly   371 ILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            .||.| ||:.|:.|||.|||||..|||||....|:.:.::| :.:.|||
Human   378 KLTDH-GLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRA-VTITDLR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_651796.1	USP8_dimer	11..120	CDD:462647	53/111 (48%)
		MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
STAMBP	NP_006454.1	Interaction with CHMP3. /evidence=ECO:0000269|PubMed:17146056	1..127		55/121 (45%)
		USP8_dimer	13..117	CDD:462647	49/103 (48%)
		Interaction with STAM. /evidence=ECO:0000269|PubMed:10383417	227..231		1/3 (33%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)