DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2224 and stambp

DIOPT Version :9

Sequence 1:	NP_001263108.1	Gene:	CG2224 / 43617	FlyBaseID:	FBgn0039773	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_001120237.1	Gene:	stambp / 100145287	XenbaseID:	XB-GENE-5926871	Length:	416	Species:	Xenopus tropicalis

Alignment Length:	432	Identity:	183/432 - (42%)
Similarity:	257/432 - (59%)	Gaps:	41/432 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SMGDVEPQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73
            |...:.|:||::.|...|..:||:.::|..||||||.||:||||:|..||:.|||||||.:|:||
Frog     5 SDASLPPEERLRALVLKGTSVEVNDDIPPKRYYRSGVEMIRMANIYAGEGSTENAFILYNKYITL 69

  Fly    74 FIEKIRQHPDYGSVKA-EVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQFLASKEAERVKELE 137
            ||||:.:|.||.:..| |.:|..:|:|:...|..|:|:.:|...|::||:::     :|:.::.|
Frog    70 FIEKLPKHRDYKTANAPEKKDTLKKLKEVAFPKAEELKKELHKRYKKEYDEY-----SEKKRKEE 129

  Fly   138 RERERERERQRQKEREKAGSSAIPSLIPANLHVLIDEGNQPSAPDLGLLDQVVYPNDFPTGANRS 202
            .||.|.:..|:|.:.||.             .|.:.:..|.........::::...:......|.
Frog   130 EERSRRQALQQQLDAEKQ-------------RVALMKQQQEQQEQFQAFEEMIRRKELEAERLRI 181

  Fly   203 L---------PGS--GLLLPAASEAAADKTTNS-------KPSFDRNQKPSY--NRTDSLLAGSL 247
            |         |||  |||:|..:|........|       .|:.||:.|||.  :....:.:..|
Frog   182 LHQFSKDDSEPGSPGGLLIPGVNEPPVTSLLPSYGTIQPHPPAVDRSLKPSSYGSHRSGVTSDGL 246

  Fly   248 RLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCNTMHEEQI 312
            |.|.:|.|....||:|:..||.:.:||||:|.|.|.||:..:||:|.|:|.|.||.|||..||::
Frog   247 RHVKIPRDVCCKFLQLSENNTQRGVETCGILCGKLMQNEFTVTHVIVPKQSGGPDYCNTESEEEL 311

  Fly   313 FDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFFILTPHYG 377
            |.:|||..|||||||||||||||||||||||||||||:|:||::||||:||:..||||.|| .||
Frog   312 FLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLT-DYG 375

  Fly   378 LDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419
            :..|..|||.|||||..|||||..:.|:.:..| .:.|:|||
Frog   376 MKEIGDCRQKGFHPHCKDPPLFSASSHVSVTEQ-DVTVMDLR 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2224	NP_001263108.1	USP8_dimer	16..119	CDD:286108	49/103 (48%)
CG2224	NP_001263108.1	MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)
stambp	NP_001120237.1	USP8_dimer	13..115	CDD:286108	48/101 (48%)
stambp	NP_001120237.1	MPN_AMSH_like	246..416	CDD:163697	100/171 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4514
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4719
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2431
OMA	1	1.010	-	-		QHG49824
OrthoDB	1	1.010	-	-		D411229at2759
OrthoFinder	1	1.000	-	-		FOG0002716
OrthoInspector	1	1.000	-	-		otm48652
Panther	1	1.100	-	-	LDO	PTHR12947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1584
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080