DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aralar1 and SLC25A18

DIOPT Version :9

Sequence 1:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_011544451.1	Gene:	SLC25A18 / 83733	HGNCID:	10988	Length:	410	Species:	Homo sapiens

Alignment Length:	428	Identity:	142/428 - (33%)
Similarity:	194/428 - (45%)	Gaps:	92/428 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LAAQTMSQITPLEIDILFHLAGAVHQAGWWKRRRKIP--------------PSSRIDYSDLSNIA 321
            ||||..|::.|                |:.||:|.:|              |...:......|..
Human     6 LAAQQRSELYP----------------GFQKRQRFLPKAGEEAAAQGGRHLPGRWLGPGCTQNPC 54

  Fly   322 PEHYTKHMTHRLAEIKAVES-----PADRSAFIQVLESSYRFT-----------LGSFAGAVGAT 370
            ..|.......|...:...:|     |.:.:|....:.|..|.|           .|..||.||.|
Human    55 SVHTATGPEPRKLPLLPPDSPNSGYPKEPAALCPGIPSPCRMTHQDLSITAKLINGGVAGLVGVT 119

  Fly   371 VVYPIDLVKTRMQNQRAGSYIGEVAYRNSWDCFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLT 435
            .|:||||.|||:|||.     |:..|:...||..|..|.|||.|:|||....|..|.|||||||.
Human   120 CVFPIDLAKTRLQNQH-----GKAMYKGMIDCLMKTARAEGFFGMYRGAAVNLTLVTPEKAIKLA 179

  Fly   436 VNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTNPLEIVKIRLQVAGEIA------------ 488
            .||..|..|.:.........|:|||..||..|||.|.|:|::||:||.||.:|
Human   180 ANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPST 244

  Fly   489 -----SGS---------KIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAM---- 535
                 :||         .:.||.::|..||.|||:|..|.||||:|||.||||.:|:...:
Human   245 SRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNE 309

  Fly   536 MADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARS-GQTTYTGVWDATKKIMAEEG 599
            :|.|..:.|.   ..:|.:||..||..|||.||:|||:|.:.:. |:..|:|:.|..:|:..:||
Human   310 LAGKASFAHS---FVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEG 371

  Fly   600 PRAFWKGTAARVFRSSPQFGVTLVTYELLQRLFYVDFG 637
            |.||.||...|....:|.||:.       |.::::..|
Human   372 PSAFMKGAGCRALVIAPLFGIA-------QGVYFIGIG 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234
		EFh	84..135	CDD:298682
		EF-hand_7	111..173	CDD:290234
		Mito_carr	350..448	CDD:278578	46/108 (43%)
		PTZ00169	358..631	CDD:240302	121/314 (39%)
		Mito_carr	449..539	CDD:278578	44/119 (37%)
		Mito_carr	544..633	CDD:278578	32/89 (36%)
SLC25A18	XP_011544451.1	Mito_carr	99..192	CDD:278578	43/97 (44%)
		PTZ00168	107..400	CDD:185494	120/307 (39%)
		Mito_carr	201..305	CDD:278578	42/103 (41%)
		Mito_carr	312..397	CDD:278578	33/94 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4126
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940