Protein Alignment aralar1 and Slc25a12

DIOPT Version :10

• Sequence 1: NP_001247368.1
• Gene: aralar1 / 43616
• FlyBaseID: FBgn0028646
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_766024.1
• Gene: Slc25a12 / 78830
• MGIID: 1926080
• Length: 677
• Species: Mus musculus
• Alignment Length: 687
• Identity: 393/687 - (57%)
• Similarity: 504/687 - (73%)
• Gaps: 26/687 - (3%)

  Fly    28 KRAGTEKLREVFLKYASIQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDGLIS 92
            ||....:||.:||:|||.:.:||||||.||||:::|||:::...|.:.|:|||.:||.:||||||
Mouse     9 KRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLIS 73

  Fly    93 FSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKRYFG 157
            :.||.|||.:||.||:::..||||||:.|||.|::.:..::..:|.:|..|||:.|..||:.:||
Mouse    74 YQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFG 138

  Fly   158 DKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRDNLV 222
            ..:::.:||.||||.|.:...|||.:||..||.:.:|.||.|||.|::|.::.|:|||.|.:|||
Mouse   139 HNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLV 203

  Fly   223 SVTEG---HKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTDM-ITKDQILLAAQTMSQITPLE 283
            |...|   |:|||.||.||.||||||||::::| ....|:|.|: :||::...:|....|:||||
Mouse   204 SAAGGGTSHQVSFSYFNAFNSLLNNMELVRKIY-STLAGTRKDIEVTKEEFAQSAIRYGQVTPLE 267

  Fly   284 IDILFHLAGAVHQAGWWKRRRKIPPSSRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPA-DRSA 347
            ||||:.||...:.:|            |:..:|:..||| .....:.:.|||::..:||. .|..
Mouse   268 IDILYQLADLYNASG------------RLTLADIERIAP-LAEGALPYNLAELQRQQSPGLGRPI 319

  Fly   348 FIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQR-AGSYIGEVAYRNSWDCFKKVVRHEG 411
            ::|:.||:|||||||.|||||||.||||||||||||||| .||.:||:.|:||:||||||:|:||
Mouse   320 WLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEG 384

  Fly   412 FMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTNPLEI 476
            |.||||||:|||:||||||||||||||.||||.|.:.|:||..||:|||||||.|||:|||||||
Mouse   385 FFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTKRDGSIPLPAEILAGGCAGGSQVIFTNPLEI 449

  Fly   477 VKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADKDG 541
            |||||||||||.:|.::.|.:|:::||||||||||:||.|||:||||||||.|||.|.::||::|
Mouse   450 VKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENG 514

  Fly   542 YNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPRAFWKG 606
            ....:.||.|||:|||||||||||||||||||||.||:|||||:||.|..:||:.||||.|||||
Mouse   515 RVGGINLLTAGALAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVVDCFRKILREEGPSAFWKG 579

  Fly   607 TAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSEAHKITTPLEQAAASVTTENVDHIGGY 671
            ||||||||||||||||||||||||.||:||||.:|.|||    .|| :...|.:...|.||||||
Mouse   580 TAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSE----PTP-KSRIADLPPANPDHIGGY 639

  Fly   672 RAAVPLLAGVESKFGLYLPRF-GRGVTAASPSTATGS 707
            |.|....||:|:|||||||:| ...|..|.|..|..:
Mouse   640 RLATATFAGIENKFGLYLPKFKSPSVAVAQPKAAAAA 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	FRQ1	32..178	CDD:444056	69/145 (48%)
		Mito_carr	350..448	CDD:395101	77/98 (79%)
		Mito_carr	449..539	CDD:395101	64/89 (72%)
		Mito_carr	544..633	CDD:395101	71/88 (81%)
Slc25a12	NP_766024.1	Regulatory N-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746	2..294		134/297 (45%)
		FRQ1	12..125	CDD:444056	54/112 (48%)
		Linker loop domain. /evidence=ECO:0000250|UniProtKB:O75746	295..310		3/14 (21%)
		Carrier domain. /evidence=ECO:0000250|UniProtKB:O75746	320..612		219/291 (75%)
		Mito_carr	327..420	CDD:395101	74/92 (80%)
		Mito_carr	422..513	CDD:395101	65/90 (72%)
		Mito_carr	519..609	CDD:395101	73/89 (82%)
		C-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746	613..677		31/69 (45%)