DRSC/TRiP Functional Genomics Resources

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Protein Alignment aralar1 and Slc25a12

DIOPT Version :9

Sequence 1:NP_001247368.1 Gene:aralar1 / 43616 FlyBaseID:FBgn0028646 Length:707 Species:Drosophila melanogaster
Sequence 2:NP_766024.1 Gene:Slc25a12 / 78830 MGIID:1926080 Length:677 Species:Mus musculus


Alignment Length:687 Identity:393/687 - (57%)
Similarity:504/687 - (73%) Gaps:26/687 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KRAGTEKLREVFLKYASIQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDGLIS 92
            ||....:||.:||:|||.:.:||||||.||||:::|||:::...|.:.|:|||.:||.:||||||
Mouse     9 KRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLIS 73

  Fly    93 FSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKRYFG 157
            :.||.|||.:||.||:::..||||||:.|||.|::.:..::..:|.:|..|||:.|..||:.:||
Mouse    74 YQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFG 138

  Fly   158 DKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRDNLV 222
            ..:::.:||.||||.|.:...|||.:||..||.:.:|.||.|||.|::|.::.|:|||.|.:|||
Mouse   139 HNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLV 203

  Fly   223 SVTEG---HKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTDM-ITKDQILLAAQTMSQITPLE 283
            |...|   |:|||.||.||.||||||||::::| ....|:|.|: :||::...:|....|:||||
Mouse   204 SAAGGGTSHQVSFSYFNAFNSLLNNMELVRKIY-STLAGTRKDIEVTKEEFAQSAIRYGQVTPLE 267

  Fly   284 IDILFHLAGAVHQAGWWKRRRKIPPSSRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPA-DRSA 347
            ||||:.||...:.:|            |:..:|:..||| .....:.:.|||::..:||. .|..
Mouse   268 IDILYQLADLYNASG------------RLTLADIERIAP-LAEGALPYNLAELQRQQSPGLGRPI 319

  Fly   348 FIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQR-AGSYIGEVAYRNSWDCFKKVVRHEG 411
            ::|:.||:|||||||.|||||||.||||||||||||||| .||.:||:.|:||:||||||:|:||
Mouse   320 WLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEG 384

  Fly   412 FMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTNPLEI 476
            |.||||||:|||:||||||||||||||.||||.|.:.|:||..||:|||||||.|||:|||||||
Mouse   385 FFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTKRDGSIPLPAEILAGGCAGGSQVIFTNPLEI 449

  Fly   477 VKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMADKDG 541
            |||||||||||.:|.::.|.:|:::||||||||||:||.|||:||||||||.|||.|.::||::|
Mouse   450 VKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENG 514

  Fly   542 YNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPRAFWKG 606
            ....:.||.|||:|||||||||||||||||||||.||:|||||:||.|..:||:.||||.|||||
Mouse   515 RVGGINLLTAGALAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVVDCFRKILREEGPSAFWKG 579

  Fly   607 TAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSEAHKITTPLEQAAASVTTENVDHIGGY 671
            ||||||||||||||||||||||||.||:||||.:|.|||    .|| :...|.:...|.||||||
Mouse   580 TAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSE----PTP-KSRIADLPPANPDHIGGY 639

  Fly   672 RAAVPLLAGVESKFGLYLPRF-GRGVTAASPSTATGS 707
            |.|....||:|:|||||||:| ...|..|.|..|..:
Mouse   640 RLATATFAGIENKFGLYLPKFKSPSVAVAQPKAAAAA 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aralar1NP_001247368.1 EF-hand_7 35..99 CDD:290234 35/63 (56%)
EF-hand_8 51..99 CDD:290545 26/47 (55%)
EF-hand_7 81..134 CDD:290234 27/52 (52%)
EFh 84..135 CDD:298682 26/50 (52%)
EF-hand_7 111..173 CDD:290234 26/61 (43%)
Mito_carr 350..448 CDD:278578 77/98 (79%)
PTZ00169 358..631 CDD:240302 208/273 (76%)
Mito_carr 449..539 CDD:278578 64/89 (72%)
Mito_carr 544..633 CDD:278578 71/88 (81%)
Slc25a12NP_766024.1 N-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746 2..294 134/297 (45%)
EFh_PEF 14..>119 CDD:330173 52/104 (50%)
EFh_MICU 91..>160 CDD:333716 27/68 (40%)
EF-hand motif 91..115 CDD:320080 10/23 (43%)
EF-hand motif 132..160 CDD:320080 11/27 (41%)
Linker loop domain. /evidence=ECO:0000250|UniProtKB:O75746 295..310 3/14 (21%)
Carrier domain. /evidence=ECO:0000250|UniProtKB:O75746 320..612 219/291 (75%)
Mito_carr 327..420 CDD:278578 74/92 (80%)
Mito_carr 422..513 CDD:278578 65/90 (72%)
Mito_carr 522..609 CDD:278578 72/86 (84%)
C-terminal domain. /evidence=ECO:0000250|UniProtKB:O75746 613..677 31/69 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845975
Domainoid 1 1.000 166 1.000 Domainoid score I3869
eggNOG 1 0.900 - - E1_KOG0751
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H48235
Inparanoid 1 1.050 767 1.000 Inparanoid score I540
Isobase 1 0.950 - 0.864974 Normalized mean entropy S1241
OMA 1 1.010 - - QHG55987
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002875
OrthoInspector 1 1.000 - - otm44350
orthoMCL 1 0.900 - - OOG6_102019
Panther 1 1.100 - - O PTHR45678
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4126
SonicParanoid 1 1.000 - - X1902
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

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