DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aralar1 and PMP34

DIOPT Version :9

Sequence 1:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001246615.1	Gene:	PMP34 / 38532	FlyBaseID:	FBgn0052250	Length:	314	Species:	Drosophila melanogaster

Alignment Length:	333	Identity:	85/333 - (25%)
Similarity:	136/333 - (40%)	Gaps:	72/333 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 SAFIQVLESSYRFTLGSFAGAVGATVV----YPIDLVKTRMQNQRAGSYIGEVAYRNSWDCFKKV 406
            |...|||  ||:..:.:.:||.|..:.    ||:|.|::|:|.:.||.      .|::....|::
  Fly     5 SKLSQVL--SYQNFVHAVSGAAGGCIAMSTFYPLDTVRSRLQLEEAGD------VRSTRQVIKEI 61

  Fly   407 VRHEGFMGLYRGLLPQLMGVAPEK--------AIKLTVNDLVRDKLTDKKGNIPT----WAEVLA 459
            |..|||..|||||.|.|..:....        |:|...:           |..|:    ..::|.
  Fly    62 VLGEGFQSLYRGLGPVLQSLCISNFVYFYTFHALKAVAS-----------GGSPSQHSALKDLLL 115

  Fly   460 GGCAGASQVVFTNPLEIVKIRLQ---VAG----------EIASGSKIRAWSVVRELGLFGLYKGA 511
            |..||...|:.|.|..:|..||:   |||          .:..|.|.    |..:.|:.||:.|.
  Fly   116 GSIAGIINVLTTTPFWVVNTRLRMRNVAGTSDEVNKHYKNLLEGLKY----VAEKEGIAGLWSGT 176

  Fly   512 RACLLRDVPFSAIYFPTYAHTKA-MMADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQV 575
            ...|:. |...|:.|..|...|. :|....|....|:....||||...|..|..|..:::|:.:.
  Fly   177 IPSLML-VSNPALQFMMYEMLKRNIMRFTGGEMGSLSFFFIGAIAKAFATVLTYPLQLVQTKQRH 240

  Fly   576 VAR---SGQTTYTGVWDATK-------KIMAEEGPRAFWKGTAARVFRSSPQFGVTLVTYE---- 626
            .::   |..:|..|....|:       .|:..:|.|..::|..|::.::.....:..:.||
  Fly   241 RSKESDSKPSTSAGSTPRTESTLELMISILQHQGIRGLFRGLEAKILQTVLTAALMFMAYEKIAG 305

  Fly   627 ----LLQR 630
                ||:|
  Fly   306 TVGMLLKR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234
		EFh	84..135	CDD:298682
		EF-hand_7	111..173	CDD:290234
		Mito_carr	350..448	CDD:278578	31/109 (28%)
		PTZ00169	358..631	CDD:240302	79/321 (25%)
		Mito_carr	449..539	CDD:278578	29/107 (27%)
		Mito_carr	544..633	CDD:278578	23/105 (22%)
PMP34	NP_001246615.1	Mito_carr	15..96	CDD:278578	25/86 (29%)
		Mito_carr	105..202	CDD:278578	26/101 (26%)
		Mito_carr	214..303	CDD:278578	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840