Protein Alignment aralar1 and Slc25a13

DIOPT Version :10

• Sequence 1: NP_001247368.1
• Gene: aralar1 / 43616
• FlyBaseID: FBgn0028646
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001406553.1
• Gene: Slc25a13 / 362322
• RGDID: 1565889
• Length: 676
• Species: Rattus norvegicus
• Alignment Length: 694
• Identity: 394/694 - (56%)
• Similarity: 494/694 - (71%)
• Gaps: 35/694 - (5%)

  Fly    25 SLLKRAGTEKLREVFLKYASIQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDG 89
            :|.|||...:|:.:|||||||:||||.:|:..|||.::|.:|.||..|.::|.||:.:.|.:|||
  Rat     7 ALTKRADPAELKAIFLKYASIEKNGEFFMSPHDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDG 71

  Fly    90 LISFSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKR 154
            ||||.||.|||.:||.||||:..||||||:.|.|.|::.|...|..:|.:|..|||:.|..|::.
  Rat    72 LISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVRQVFGQTTIHQHIPFNWDSEFVQL 136

  Fly   155 YFGDKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRD 219
            :||.:::|.:.||||||.|.:...|||.:||..:|.|.||.::.:||:||:|.::.|:|||.|.:
  Rat   137 HFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAKTGKVTAIDFRDIMVTIRPHVLTPFVEE 201

  Fly   220 NLVSV---TEGHKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTDM-ITKDQILLAAQTMSQIT 280
            .||:.   |..|:|||.||..|.|||||||||:::| ....|||.|: :||::..||||...|:|
  Rat   202 CLVAAAGGTRSHQVSFSYFNGFNSLLNNMELIRKIY-STLAGSRKDVEVTKEEFALAAQKFGQVT 265

  Fly   281 PLEIDILFHLAGAVHQAGWWKRRRKIPPSSRIDYSDLSNIAPEHYTKHMTHRLAEI---KAVESP 342
            |:|:||||.||....            |..|:..:|:..|||.. ...:...|||.   :.....
  Rat   266 PMEVDILFQLADLYE------------PRGRMTLADIERIAPLE-EGMLPFNLAEAQRQQKASGD 317

  Fly   343 ADRSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRA-GSYIGEVAYRNSWDCFKKV 406
            |.|...:|:.||:|||.|||.|||||||.|||||||||||||||: ||::||:.|:||:||||||
  Rat   318 AARPFLLQLAESAYRFGLGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKV 382

  Fly   407 VRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFT 471
            :|:|||.||||||||||:||||||||||||||.||||...|.|::|..||:.||||||.|||:||
  Rat   383 LRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLLAEIFAGGCAGGSQVIFT 447

  Fly   472 NPLEIVKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMM 536
            ||||||||||||||||.:|.::.|.||||:||.||:||||:||.|||:||||||||.|||.||..
  Rat   448 NPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASF 512

  Fly   537 ADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPR 601
            |::||...|.:||.||||||:||||||||||||||||||.||:|||||:||.|..:||:.||||:
  Rat   513 ANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVTDCFRKILREEGPK 577

  Fly   602 AFWKGTAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSE---AHKITTPLEQAAASVTTE 663
            |.|||..||||||||||||||:|||||||.|||||||.:|.|||   ..:||.|         ..
  Rat   578 ALWKGAGARVFRSSPQFGVTLLTYELLQRWFYVDFGGVKPVGSELVPKSRITLP---------AP 633

  Fly   664 NVDHIGGYRAAVPLLAGVESKFGLYLPRFGRGVTAASPSTATGS 707
            |.||:|||:.||...||:|:|||||||.| :...:.|..||.||
  Rat   634 NPDHVGGYKLAVATFAGIENKFGLYLPLF-KPSASTSKVTAVGS 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	FRQ1	32..178	CDD:444056	71/145 (49%)
		Mito_carr	350..448	CDD:395101	76/98 (78%)
		Mito_carr	449..539	CDD:395101	64/89 (72%)
		Mito_carr	544..633	CDD:395101	68/88 (77%)
Slc25a13	NP_001406553.1	Regulatory N-terminal domain. /evidence=ECO:0000250|UniProtKB:Q9UJS0	2..295		138/300 (46%)
		EF-hand_7	18..81	CDD:463900	33/62 (53%)
		EFh_PEF	<56..183	CDD:355382	59/126 (47%)
		EF-hand motif	57..83	CDD:320060	15/25 (60%)
		EF-hand motif	84..126	CDD:320060	19/41 (46%)
		EF-hand motif	133..159	CDD:320060	11/25 (44%)
		Linker loop domain. /evidence=ECO:0000250|UniProtKB:O75746	296..312		3/16 (19%)
		Carrier domain. /evidence=ECO:0000250|UniProtKB:Q9UJS0	322..613		215/290 (74%)
		Mito_carr	330..423	CDD:395101	73/92 (79%)
		Mito_carr	425..512	CDD:395101	63/86 (73%)
		Mito_carr	517..609	CDD:395101	69/91 (76%)
		C-terminal domain. /evidence=ECO:0000250|UniProtKB:Q9UJS0	614..676		30/71 (42%)