DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aralar1 and slc25a12

DIOPT Version :9

Sequence 1:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_997947.1	Gene:	slc25a12 / 337675	ZFINID:	ZDB-GENE-031006-11	Length:	682	Species:	Danio rerio

Alignment Length:	687	Identity:	391/687 - (56%)
Similarity:	489/687 - (71%)	Gaps:	28/687 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLKRAGTEKLREVFLKYAS-IQKNGEHYMTSEDFVRKFLGLFSESAFNDESVRLLANIADTSKDG 89
            |.|||....|:.:|.|||| :.|:||.|||..|||:::|||.::..||.::|.|||.:|||:|||
Zfish     7 LTKRADPNDLKVIFQKYASVVDKDGERYMTPIDFVQRYLGLHTQLHFNPKTVHLLAGVADTTKDG 71

  Fly    90 LISFSEFQAFEGLLCTPDALYRTAFQLFDRKGNGTVSYADFADVVQKTELHSKIPFSLDGPFIKR 154
            |||:.||.|||.:||.||||:..||||||:.|.|.||:.:..|:..:|.:|..|||:.|..||:.
Zfish    72 LISYQEFLAFESVLCMPDALFIVAFQLFDKTGTGDVSFENVRDIFSQTTVHHHIPFNWDCEFIRL 136

  Fly   155 YFGDKKQRLINYAEFTQLLHDFHEEHAMEAFRSKDPAGTGFISPLDFQDIIVNVKRHLLTPGVRD 219
            :||:.:.:.::|.||.|.|.:...|||.:||..||...:|.||.|||.||:..::.|:|||.|.:
Zfish   137 HFGNARNKRLSYLEFGQFLQELQLEHARQAFVQKDKVKSGMISSLDFSDIMSTIRHHMLTPFVEE 201

  Fly   220 NLVSVTEG---HKVSFPYFIAFTSLLNNMELIKQVYLHATEGSRTD-MITKDQILLAAQTMSQIT 280
            ||||...|   |.|||.||.||.|||||||:|:::| ....|||.| ::||::.:.||....|||
Zfish   202 NLVSAAGGGTSHMVSFSYFNAFNSLLNNMEMIRKIY-STLAGSRKDTLVTKEEFVHAANKFGQIT 265

  Fly   281 PLEIDILFHLAGAVHQAGWWKRRRKIPPSSRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPAD- 344
            |:||||||.|:|...|.|            |::.:|:..|||.. ...:.:.:||.:...|..:
Zfish   266 PMEIDILFQLSGLHSQTG------------RLNMTDIERIAPLE-EGSLPYNVAEAQRQHSHGEV 317

  Fly   345 -RSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRA-GSYIGEVAYRNSWDCFKKVV 407
             |..::|..||:|||||||.|||.|||.|||||||||||||||: ||::||:.|:||:||.|||:
Zfish   318 SRPVWLQAAESAYRFTLGSIAGATGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCAKKVL 382

  Fly   408 RHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEVLAGGCAGASQVVFTN 472
            |:|||.|.||||||||:||||||||||||||.||||.|.....||..||:|||||||.|||:|||
Zfish   383 RYEGFFGFYRGLLPQLIGVAPEKAIKLTVNDFVRDKFTTNDDTIPLAAEILAGGCAGGSQVIFTN 447

  Fly   473 PLEIVKIRLQVAGEIASGSKIRAWSVVRELGLFGLYKGARACLLRDVPFSAIYFPTYAHTKAMMA 537
            |||||||||||||||.:|.::.|.||:|:||.||||||.:||.|||:||||||||.||||||::|
Zfish   448 PLEIVKIRLQVAGEITTGPRVSALSVIRDLGFFGLYKGTKACFLRDIPFSAIYFPVYAHTKALLA 512

  Fly   538 DKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQVVARSGQTTYTGVWDATKKIMAEEGPRA 602
            |:||....|.||:|||||||||||||||||||||||||.||:|||||.||.|..:|||.|||.||
Zfish   513 DEDGRLGALQLLSAGAIAGVPAASLVTPADVIKTRLQVAARAGQTTYNGVIDCFRKIMKEEGFRA 577

  Fly   603 FWKGTAARVFRSSPQFGVTLVTYELLQRLFYVDFGGTQPKGSEAHKITTPLEQAAASVTTENVDH 667
            .|||..||||||||||.|||:|||||||..||||||.:|.|||    .|| :...:.:...:.:|
Zfish   578 LWKGAGARVFRSSPQFAVTLLTYELLQRWLYVDFGGHRPAGSE----PTP-KSRISELPPVSSEH 637

  Fly   668 IGGYRAAVPLLAGVESKFGLYLPRF-GRGVTAASPST 703
            :||||.|....||||:||||:||:| ..|::...|.|
Zfish   638 VGGYRLAAATFAGVENKFGLHLPKFKSSGISTIHPET 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234	35/64 (55%)
		EF-hand_8	51..99	CDD:290545	26/47 (55%)
		EF-hand_7	81..134	CDD:290234	31/52 (60%)
		EFh	84..135	CDD:298682	30/50 (60%)
		EF-hand_7	111..173	CDD:290234	25/61 (41%)
		Mito_carr	350..448	CDD:278578	75/98 (77%)
		PTZ00169	358..631	CDD:240302	206/273 (75%)
		Mito_carr	449..539	CDD:278578	65/89 (73%)
		Mito_carr	544..633	CDD:278578	69/88 (78%)
slc25a12	NP_997947.1	EF-hand_7	16..81	CDD:290234	35/64 (55%)
		Mito_carr	329..422	CDD:278578	72/92 (78%)
		PTZ00169	332..607	CDD:240302	207/274 (76%)
		Mito_carr	424..511	CDD:278578	64/86 (74%)
		Mito_carr	516..608	CDD:278578	70/91 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590687
Domainoid	1	1.000	161	1.000	Domainoid score	I3981
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48235
Inparanoid	1	1.050	745	1.000	Inparanoid score	I563
OMA	1	1.010	-	-		QHG55987
OrthoDB	1	1.010	-	-		D1007928at2759
OrthoFinder	1	1.000	-	-		FOG0002875
OrthoInspector	1	1.000	-	-		otm26130
orthoMCL	1	0.900	-	-		OOG6_102019
Panther	1	1.100	-	-	O	PTHR45678
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1902
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910