DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aralar1 and CG5254

DIOPT Version :9

Sequence 1:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_569856.2	Gene:	CG5254 / 31020	FlyBaseID:	FBgn0040383	Length:	306	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	95/305 - (31%)
Similarity:	151/305 - (49%)	Gaps:	37/305 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 SPADRSAFIQVLESSYRFTLGSFAGAVGATVVYPIDLVKTRMQNQRA----GSYIGEVAYRNSWD 401
            |.|.|:|| |||       .|..||.:...::.|:|:||||:|.|..    .:.:|||.|...:|
  Fly     9 SHAKRAAF-QVL-------AGGSAGFLEVCIMQPLDVVKTRIQIQATPAPNAAALGEVHYNGVFD 65

  Fly   402 CFKKVVRHEGFMGLYRGLLPQLMGVAPEKAIKLTVNDLVRDKLTDKKGNIPTWAEV---LAGGCA 463
            ||.|:.||||....::|::|.::...|::|||..|.:  :.|...:.|: ||...:   |||..|
  Fly    66 CFAKMYRHEGISSYWKGIMPPILAETPKRAIKFLVFE--QTKPLFQFGS-PTPTPLTFSLAGLTA 127

  Fly   464 GASQVVFTNPLEIVKIRLQVAGE--------IASGSKIRAWSVVRE--LGLFGLYKGARACLLRD 518
            |..:.:..||.|:||:..|...:        :|.|       ::::  ||..||.||..|.:.|:
  Fly   128 GTLEAIAVNPFEVVKVAQQADRQKKMLSTFAVAKG-------IIQQDGLGFSGLNKGITATMGRN 185

  Fly   519 VPFSAIYFPTYAHTKAMMAD-KDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRLQ-VVARSGQ 581
            ..|:.:||..|...|.::.: |:.:...|..:..|.:||..|..:..|.||.|:|:| .....||
  Fly   186 GVFNMVYFGFYHSVKNVVPEYKESHLEFLRKVTIGFLAGTLACFVNIPFDVAKSRIQGPQPVPGQ 250

  Fly   582 TTYTGVWDATKKIMAEEGPRAFWKGTAARVFRSSPQFGVTLVTYE 626
            ..|.|...:...:..|||.||.:||...::.|..|...:.|:.:|
  Fly   251 IKYRGTLSSMGIVYREEGFRALYKGLVPKIMRLGPGGAILLLVFE 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234
		EFh	84..135	CDD:298682
		EF-hand_7	111..173	CDD:290234
		Mito_carr	350..448	CDD:278578	34/101 (34%)
		PTZ00169	358..631	CDD:240302	87/288 (30%)
		Mito_carr	449..539	CDD:278578	29/103 (28%)
		Mito_carr	544..633	CDD:278578	26/84 (31%)
CG5254	NP_569856.2	Mito_carr	18..112	CDD:278578	33/102 (32%)
		PTZ00169	19..301	CDD:240302	88/294 (30%)
		Mito_carr	122..207	CDD:278578	26/91 (29%)
		Mito_carr	209..305	CDD:278578	26/87 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840