DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15534 and smpdl3a

DIOPT Version :9

Sequence 1:	NP_651792.1	Gene:	CG15534 / 43613	FlyBaseID:	FBgn0039769	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001025618.2	Gene:	smpdl3a / 595006	XenbaseID:	XB-GENE-955002	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	459	Identity:	132/459 - (28%)
Similarity:	222/459 - (48%)	Gaps:	63/459 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 LTLSIQGDLPQESNSNLPAKTSEDILVLHLTDIHYDPEYAEGSNAACDEPMCCRNSLPEGSDSSA 253
            :.||.:|:..||..:.         ...|::|:|.|..|    :...|....|.:|  :|:.:|
Frog    19 MPLSPEGNPTQEETAG---------QFWHISDLHLDFSY----HITEDRTKVCLSS--KGAKAS- 67

  Fly   254 AAGFWSDYRDCDCPKRLILSAFEHIKENH-KIEWIYHTGDVPPH-NVWSTTRQGNLDMLSEIDEL 316
            ..|.:.|: .||.|..|||||.::||::| |::::..|||.||| .|...:.:..:|::..:...
Frog    68 NPGIFGDF-VCDSPYELILSAIQYIKDSHQKVDFMIWTGDSPPHIPVKELSTKIVIDVIGNMTST 131

  Fly   317 LAKYFPDTPIYPCLGNHEPHPANVFGNDEIPSSLRVDWLYEHVWSLWSKWLPAEAEETVLRGGYY 381
            :....||..::|.||||:..|     .|::|  ::...:|..|...|..||..||..|..:||||
Frog   132 IRSLLPDLLVFPALGNHDYWP-----QDQLP--VKESEVYTAVAEFWKPWLTEEALSTFRKGGYY 189

  Fly   382 T---ASPSKGH--RIVALNSMDCYLYNWWLFYNATLIQEQLQWFHDTLLSAEEAGESVHILTHIP 441
            :   .|....|  ||::||:...|..| .:..|.|....|.:|..|||..:.:..|.|:|:.|:|
Frog   190 SQIYKSNKSAHSLRIISLNTNLYYTPN-KVTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVP 253

  Fly   442 AGDGDCWCNWS-------QEYN----RVLTRFNGIITGVFSGHTHKDEMNLHYSE------DGYA 489
            .|    :..::       :.:|    ::...::.:||..|.||||:|.:.:...|      ..:.
Frog   254 VG----YLPFARLTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLDEKEKPVGSVFV 314

  Fly   490 T-VVNWNGGSLTSYSNKNPNYRLYELHPENWQVLDHHTYTFNLTEANLTPDEQPKWELEYQFTKE 553
            | .|.....:|.:.|| ||.:|||:....::.:||...|..|||||||  ..:..|.|||..||.
Frog   315 TPAVTPIRSALETDSN-NPGFRLYQYDTTDYHLLDLWHYFLNLTEANL--KNESSWNLEYIMTKT 376

  Fly   554 Y-TEDTSPAGIDRLLLEMAEKPDLLR--KFWRNKFTNSDPKLAEGCDNACLSKTICRIATSNYQE 615
            | .:|..|..::. |::..::|:.:.  .:::|...:.|.::  |||..|..:.||.|...:.:.
Frog   377 YQIKDLQPESLEG-LVKRFQQPESIEFLYYYKNYLVSFDSRV--GCDPLCKLQQICAIQYVDEES 438

  Fly   616 RTRC 619
            .|:|
Frog   439 YTKC 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15534	NP_651792.1	MPP_ASMase	215..510	CDD:277321	92/319 (29%)
CG15534	NP_651792.1	Metallophos	271..477	CDD:278574	67/223 (30%)
smpdl3a	NP_001025618.2	MPP_ASMase	36..335	CDD:277321	92/319 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D1142100at2759
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930