Protein Alignment CG15533 and Smpd1

DIOPT Version :10

• Sequence 1: NP_651791.2
• Gene: CG15533 / 43612
• FlyBaseID: FBgn0039768
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_035551.1
• Gene: Smpd1 / 20597
• MGIID: 98325
• Length: 627
• Species: Mus musculus
• Alignment Length: 611
• Identity: 181/611 - (29%)
• Similarity: 287/611 - (46%)
• Gaps: 61/611 - (9%)

  Fly    35 DHILSAIADDIAERLAREYITFLKTGVETAEFLKLTNQL------------AKSHSEKDIFTRNM 87
            ||:.:.....:...|....:..|..|:..|..|.|.:..            ::.||.|  |:...
Mouse    11 DHLRAGWEQRLERSLPAPRVGLLWMGLGLALVLALFDSTVLWVPARAYPLPSEGHSVK--FSAIA 73

  Fly    88 PDLEPRDSF--FACVACRSVTRVLIRTIREEDGELHG---ENSSVLMKEFAMDVCRRLNLQTEEV 147
            |.|:....:  ..|.||    :||...:.      ||   |.:...:...|:.:|:.||:...:|
Mouse    74 PPLQSAFGWQNLTCPAC----KVLFTALN------HGLKKEPNVARVGSVAIKICKMLNIAPLDV 128

  Fly   148 CEG---LIDSNLPSVEYIMRNSESDSQSFCSLFMEFNFCNTGTNQDY-----NWTLTIDNTGEAS 204
            |:.   |.:.::  ||...|:..|.|:: |.|.:       |::..:     .|.:::.:..:..
Mouse   129 CQSAVHLFEDDV--VEVWTRSVLSPSEA-CGLLL-------GSSCGHWDIFSTWNISLPSVPKPP 183

  Fly   205 AGPKSDTPTFQDSDI-RICQFSDIHHDPYYTPGSLATCAEPMCCQRNKETTEGTSDAAGYWGDYR 268
              ||..:|....:.: |:...:|:|.|..|..|:...||:|:||:|.......:...||:||:|.
Mouse   184 --PKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYS 246

  Fly   269 DCDLPWHAFESALDNAVANSKCDFIYQTGDIVDHMVWATSVEKNTMVLTKVSERLNAAFGDVPVY 333
            .||||....||.|.........:.:|.||||..|.||..|.:.....||.:::.:....|.||||
Mouse   247 KCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVY 311

  Fly   334 PCIGNHEPHPLNLFSPEGVPDEISTKWLYEHLYNDWSKWLPAETKETILKGGYYTVVPRKGFRII 398
            |.:||||..|:|.|.|..:....|::||||.:...|..||||:...|:..||:|.:.||.|.|:|
Mouse   312 PAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLI 376

  Fly   399 ALNSNDCYTDNFWLYHSGTDKIPQLQWFHDTLLEAEKNGEYVHVLTHIPSGDGTCWSVWAREFNR 463
            :||.|.|..:||||..:.||...||||..:.|..||..|:.||::.|||.|.  |...|:..:.:
Mouse   377 SLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGH--CLKSWSWNYYK 439

  Fly   464 CVSRFRSTISGIFTGHSHKDELFVYYSEDE-GHPTAVAWNGGAVTTYSNKNPNYREYAVN----P 523
            .::|:.:|::|.|.||:|.||..::|.|:. ..|.|||:...:.||:.|.||.||.|.::    .
Mouse   440 IIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPG 504

  Fly   524 ETYTVTNHWTWIYNLTAANLKPDEQPEWFLEYEFIKEF-TEDMSPAGISKLLDEFAENPELMRKY 587
            .::.|.:|.|:|.|||.|| .....|.|...|...:.: ..|..||....|:....::.:|.:.:
Mouse   505 SSHVVLDHETYILNLTQAN-AAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTF 568

  Fly   588 WRYRVTSADPQVNGGCDRSCLAGSLC 613
            |........|  :..|...|...:||
Mouse   569 WFLYHKGHPP--SEPCGTPCRLATLC 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15533	NP_651791.2	SapB	99..183	CDD:214797	22/89 (25%)
		MPP_ASMase	221..517	CDD:277321	113/296 (38%)
		ASMase_C	509..613	CDD:466022	27/108 (25%)
Smpd1	NP_035551.1	SapB	85..158	CDD:214797	21/85 (25%)
		MPP_ASMase	199..494	CDD:277321	113/296 (38%)
		ASMase_C	472..593	CDD:466022	35/124 (28%)