DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2218 and ubox5

DIOPT Version :9

Sequence 1:	NP_001287613.1	Gene:	CG2218 / 43611	FlyBaseID:	FBgn0039767	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001005006.1	Gene:	ubox5 / 448492	XenbaseID:	XB-GENE-973070	Length:	539	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	155/595 - (26%)
Similarity:	239/595 - (40%)	Gaps:	174/595 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LINFLNPKLKPSVETDAVCEDGYTAANLVADDVEQLERGFMCFAVCKPPIEIVFDFPKAVDMKVI 68
            :||...|:..|.|..:.:..|||...||::||:.:..|||.|....:||:.:...||.:.::..|
Frog     2 VINLCLPQFHPRVACNKISADGYEVENLISDDLSKRNRGFRCEYFIRPPVHVTITFPCSTEICRI 66

  Fly    69 KLWPSCGALRSTAFELHGRH--DGIWERVAFVRDLGRGVDSVTFCYQSDYNSRSSSNSEQS---- 127
            .:..|.|          |:|  .||        ||              |.|.||:.|..|
Frog    67 NIDTSHG----------GQHHFSGI--------DL--------------YTSSSSTKSSWSAHDP 99

  Fly   128 ------------------------EKVFF----FKSAHKI------------------------L 140
                                    .||.|    ||..|..                        |
Frog   100 NQAGLVVPDKELFTLVGKVLLKNQSKVTFNNRAFKPRHPFHQFDHVMSYHGSSCQELWNKGPSSL 164

  Fly   141 ASTNSVKVVI-RATERCPPVLRKVQMWGLPARSLDKADRELVKTIW--SEISDPYGQRDAAQTPT 202
            |...|:|:.| ......|..:::|::||.||::..|   |:|::::  :.:|.|:......|.|:
Frog   165 AGVTSLKICITHIAGGAPCCIKRVEVWGHPAKTCPK---EIVESLYQIACLSLPHDSAQQQQQPS 226

  Fly   203 ---------------GQRSPPRNVPELRDQSTLSIPEEFLDSITWELMIFPTVLPSGKVVDQSTI 252
                           .||||......|.     ::||||||.||.::|.||.:||||||:||||:
Frog   227 LPMDSSHMLSSTLENIQRSPSELATILH-----NVPEEFLDPITLDIMTFPMLLPSGKVIDQSTL 286

  Fly   253 DKHAEEEAKWGRQPSDPFTGLEFNAQRKAILHLALKARIEKFLMENSEHFKAVPRSLGTSRQRRR 317
            ||..:.||.|||.|||||||:.||...:|:.|.:||.||:.||:::        |..|::...|.
Frog   287 DKCNQSEATWGRLPSDPFTGVPFNQHSQAVPHPSLKVRIDYFLLQH--------RMPGSNILGRT 343

  Fly   318 HASQFASSTCQPGQISPAAGTYSALSNAYK-QQQRKSRATATATSSSAASFGGSPHSPPAAKRAR 381
            ....|         ::|:|...|::....: .:...:......|..||.|...|..|..:||:.:
Frog   344 QIGPF---------VTPSAVALSSMKRKVEWMEDSDNDGDNVDTYFSAVSGFNSSASDFSAKKLK 399

  Fly   382 H----SQHGSACATVTSATTSIDQAIQQALQ---------------KVTRFSQLPSNSSAGSGSS 427
            .    ||....|:|..|...|.:|.:.|:|.               :..:..||.::..:|.|:|
Frog   400 TENDCSQSNMDCSTSNSDAASHEQRLTQSLDYALTTTLGSMPSYTARFVKGHQLGASGESGGGTS 464

  Fly   428 S----------APPASCINCR-------SAQFGYEIRTCRHLVCRECLVLLSQDQQCVCKVFFRC 475
            :          |....|.:|.       ..:..|:: :|.||:||.||....:....:|....|.
Frog   465 AWSTIPEFNRCAEGQGCSSCGRIFSAYCKTEPVYQL-SCGHLMCRPCLAEKQKSLSILCNNCNRS 528

  Fly   476 A---DVERYH 482
            .   ||:|.|
Frog   529 VATRDVQRVH 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2218	NP_001287613.1	U-box	222..300	CDD:252675	45/77 (58%)
ubox5	NP_001005006.1	RING-Ubox_RNF37	257..309	CDD:319574	35/51 (69%)
		U-box domain, a modified RING finger	262..305	CDD:319574	27/42 (64%)
		RING-HC_RNF37	480..526	CDD:319451	11/46 (24%)
		RING-HC finger (C3HC4-type)	481..525	CDD:319451	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6881
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8972
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4215
OMA	1	1.010	-	-		QHG47807
OrthoDB	1	1.010	-	-		D318818at33208
OrthoFinder	1	1.000	-	-		FOG0009564
OrthoInspector	1	1.000	-	-		oto105221
Panther	1	1.100	-	-	LDO	PTHR13492
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080