Protein Alignment CG2218 and UBOX5

DIOPT Version :9

• Sequence 1: NP_001287613.1
• Gene: CG2218 / 43611
• FlyBaseID: FBgn0039767
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_055763.1
• Gene: UBOX5 / 22888
• HGNCID: 17777
• Length: 541
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 144/593 - (24%)
• Similarity: 233/593 - (39%)
• Gaps: 168/593 - (28%)

  Fly     4 LINFLNPKLKPSVETDAVCEDGYTAANLVADDVEQLERGFMCFAVCKPPIEIVFDFPKAVDMKVI 68
            :||...|:.:|.:..:.:..|||...||:::|:.:...||......|||:.:...||..|::..|
Human     2 VINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRI 66

  Fly    69 KLWPSCGALRSTAFELHGRHDGIWERVAFVRDLGRGVDSVTFCYQSDYNSRSSSNSEQ------- 126
            .:..:.|.                         |:.|..:.. |.|..:||.|.|:.|
Human    67 NIDLTAGG-------------------------GQNVTGLEM-YTSASSSRVSWNTPQCRTLGPA 105

  Fly   127 -----SEKVF------FFKSAHKILASTNSVKV-----VIRATERCP------------------ 157
                 .::.|      ..|:..:::.|....|.     .:.||...|
Human   106 EPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHV 170

  Fly   158 ---------------PVLRKVQMWGLPARSLDKADRELVKTIWSEISDPYGQRDAAQTPT---GQ 204
                           |.::::::||.||::   ..:|::.:|....|:...|..|.|.|.   ..
Human   171 AHLRICITHVTGGGIPCIKRLEVWGQPAKT---CSQEVIDSILLVTSENLPQDVALQAPALPMES 232

  Fly   205 RSPPRNVPELRD-QSTL--------SIPEEFLDSITWELMIFPTVLPSGKVVDQSTIDKHAEEEA 260
            ...|.:.||.:. .|:|        .:||||||.||.|:|..|.:||||||:||||::|....||
Human   233 DCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEA 297

  Fly   261 KWGRQPSDPFTGLEFNAQRKAILHLALKARIEKFLMENS-----------EHFKAVPRSLGTSRQ 314
            .|||.|||||||:.|....:.:.|.:|||||:.||:::|           .....:|.|:....|
Human   298 TWGRVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSIPGCHLLGRAQTALAVIPSSIVLPSQ 362

  Fly   315 RRR--------------HASQFASSTCQPGQISPAAGTYSALSNAYKQQQRKSRATATATSSSAA 365
            :|:              :||.|::::   ..:.|....::|         :|.:||...:.:
Human   363 KRKIEQAEHVPDSNFGVNASCFSATS---PLVLPTTSEHTA---------KKMKATNEPSLT--- 412

  Fly   366 SFGGSPHSPPAAKRARHSQHGSACATVTSATTSIDQAIQQALQKVTRFSQLP------SNSSAGS 424
                  |...:.....|.|..|....:..|:|.  .::.....::|| .||.      ||:|...
Human   413 ------HMDCSTGPLSHEQKLSQSLEIALASTL--GSMPSFTARLTR-GQLQHLGTRGSNTSWRP 468

  Fly   425 GSSSAPPAS-----CINCR---SAQFG----YEIRTCRHLVCRECLVLLSQDQQCVCKVFFR--- 474
            |:.|..|.|     |.:|:   |..|.    |:: .|.||:||.||....:.....|....|
Human   469 GTGSEQPGSILGPECASCKRVFSPYFKKEPVYQL-PCGHLLCRPCLGEKQRSLPMTCTACQRPVA 532

  Fly   475 CADVERYH 482
            ..||.|.|
Human   533 SQDVLRVH 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2218	NP_001287613.1	U-box	222..300	CDD:252675	44/88 (50%)
UBOX5	NP_055763.1	RING-Ubox_RNF37	260..312	CDD:319574	34/51 (67%)
		U-box domain, a modified RING finger	265..308	CDD:319574	26/42 (62%)
		RING-HC_RNF37	482..528	CDD:319451	13/46 (28%)
		RING-HC finger (C3HC4-type)	483..527	CDD:319451	13/44 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158709
Domainoid	1	1.000	94	1.000	Domainoid score	I7512
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8972
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4657
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47807
OrthoDB	1	1.010	-	-		D318818at33208
OrthoFinder	1	1.000	-	-		FOG0009564
OrthoInspector	1	1.000	-	-		oto91450
orthoMCL	1	0.900	-	-		OOG6_110116
Panther	1	1.100	-	-	LDO	PTHR13492
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5321
SonicParanoid	1	1.000	-	-		X7312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800