Protein Alignment CG2218 and UBOX5

DIOPT Version :10

• Sequence 1: NP_651790.1
• Gene: CG2218 / 43611
• FlyBaseID: FBgn0039767
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_055763.1
• Gene: UBOX5 / 22888
• HGNCID: 17777
• Length: 541
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 144/593 - (24%)
• Similarity: 233/593 - (39%)
• Gaps: 168/593 - (28%)

  Fly     4 LINFLNPKLKPSVETDAVCEDGYTAANLVADDVEQLERGFMCFAVCKPPIEIVFDFPKAVDMKVI 68
            :||...|:.:|.:..:.:..|||...||:::|:.:...||......|||:.:...||..|::..|
Human     2 VINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRI 66

  Fly    69 KLWPSCGALRSTAFELHGRHDGIWERVAFVRDLGRGVDSVTFCYQSDYNSRSSSNSEQ------- 126
            .:..:.|.                         |:.|..:.. |.|..:||.|.|:.|
Human    67 NIDLTAGG-------------------------GQNVTGLEM-YTSASSSRVSWNTPQCRTLGPA 105

  Fly   127 -----SEKVF------FFKSAHKILASTNSVKV-----VIRATERCP------------------ 157
                 .::.|      ..|:..:::.|....|.     .:.||...|
Human   106 EPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHV 170

  Fly   158 ---------------PVLRKVQMWGLPARSLDKADRELVKTIWSEISDPYGQRDAAQTPT---GQ 204
                           |.::::::||.||::   ..:|::.:|....|:...|..|.|.|.   ..
Human   171 AHLRICITHVTGGGIPCIKRLEVWGQPAKT---CSQEVIDSILLVTSENLPQDVALQAPALPMES 232

  Fly   205 RSPPRNVPELRD-QSTL--------SIPEEFLDSITWELMIFPTVLPSGKVVDQSTIDKHAEEEA 260
            ...|.:.||.:. .|:|        .:||||||.||.|:|..|.:||||||:||||::|....||
Human   233 DCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEA 297

  Fly   261 KWGRQPSDPFTGLEFNAQRKAILHLALKARIEKFLMENS-----------EHFKAVPRSLGTSRQ 314
            .|||.|||||||:.|....:.:.|.:|||||:.||:::|           .....:|.|:....|
Human   298 TWGRVPSDPFTGVAFTPHSQPLPHPSLKARIDHFLLQHSIPGCHLLGRAQTALAVIPSSIVLPSQ 362

  Fly   315 RRR--------------HASQFASSTCQPGQISPAAGTYSALSNAYKQQQRKSRATATATSSSAA 365
            :|:              :||.|::::   ..:.|....::|         :|.:||...:.:
Human   363 KRKIEQAEHVPDSNFGVNASCFSATS---PLVLPTTSEHTA---------KKMKATNEPSLT--- 412

  Fly   366 SFGGSPHSPPAAKRARHSQHGSACATVTSATTSIDQAIQQALQKVTRFSQLP------SNSSAGS 424
                  |...:.....|.|..|....:..|:|.  .::.....::|| .||.      ||:|...
Human   413 ------HMDCSTGPLSHEQKLSQSLEIALASTL--GSMPSFTARLTR-GQLQHLGTRGSNTSWRP 468

  Fly   425 GSSSAPPAS-----CINCR---SAQFG----YEIRTCRHLVCRECLVLLSQDQQCVCKVFFR--- 474
            |:.|..|.|     |.:|:   |..|.    |:: .|.||:||.||....:.....|....|
Human   469 GTGSEQPGSILGPECASCKRVFSPYFKKEPVYQL-PCGHLLCRPCLGEKQRSLPMTCTACQRPVA 532

  Fly   475 CADVERYH 482
            ..||.|.|
Human   533 SQDVLRVH 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2218	NP_651790.1	DUF5918	6..187	CDD:466039	42/236 (18%)
		RING-Ubox_RNF37	223..275	CDD:438322	34/51 (67%)
UBOX5	NP_055763.1	DUF5918	4..217	CDD:466039	43/241 (18%)
		RING-Ubox_RNF37	260..312	CDD:438322	34/51 (67%)
		RING-HC_RNF37	481..532	CDD:438199	14/51 (27%)