Protein Alignment MRE11 and MRE11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_013951.1
• Gene: MRE11 / 855264
• SGDID: S000004837
• Length: 692
• Species: Saccharomyces cerevisiae
• Alignment Length: 705
• Identity: 254/705 - (36%)
• Similarity: 367/705 - (52%)
• Gaps: 122/705 - (17%)

Human     9 DENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLH 73
            |.:|.:||:.||.|:|:.|.|.:.|:|::.|..|::.||:.|.||.::..|||||.||||:|:|:
Yeast     5 DPDTIRILITTDNHVGYNENDPITGDDSWKTFHEVMMLAKNNNVDMVVQSGDLFHVNKPSKKSLY 69

Human    74 TCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADAL 138
            ..|:.||..||||:|.:.|:|||.|..|.:.:|..|||:|.|.|||||||.|.|||||.:|...|
Yeast    70 QVLKTLRLCCMGDKPCELELLSDPSQVFHYDEFTNVNYEDPNFNISIPVFGISGNHDDASGDSLL 134

Human   139 CALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRP 203
            |.:|||...|.:||||:.:..:||.:.|:|.||||||:|||||.::.||||:|.|.:..||...|
Yeast   135 CPMDILHATGLINHFGKVIESDKIKVVPLLFQKGSTKLALYGLAAVRDERLFRTFKDGGVTFEVP 199

Human   204 KEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGS 268
            ...|..||||..:|||.:.|.:|.|:|||||.||:|:|||||||||......|..:.|.:.||||
Yeast   200 TMREGEWFNLMCVHQNHTGHTNTAFLPEQFLPDFLDMVIWGHEHECIPNLVHNPIKNFDVLQPGS 264

Human   269 SVVTSLSPGEAVKKHVGLLRIK-GRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAI 332
            ||.|||...||..|:|.:|.|| |....|..|||.|:|.|.|:.|.|.:.|.:    .|....|.
Yeast   265 SVATSLCEAEAQPKYVFILDIKYGEAPKMTPIPLETIRTFKMKSISLQDVPHL----RPHDKDAT 325

Human   333 QSFCLEKIEEMLENAERE---RLGNSHQPE------KPLVRLRVDYSG--------GFEPFSVLR 380
            ..:.:|::|||:.:|..|   :|.:..:.:      |||:|||||||.        .::..:..|
Yeast   326 SKYLIEQVEEMIRDANEETKQKLADDGEGDMVAELPKPLIRLRVDYSAPSNTQSPIDYQVENPRR 390

Human   381 FSQKFVDRVANPKDIIHFFRHRE---QKEKTG------EEINFGKLITKPSEGTTLRVEDLVKQY 436
            ||.:||.||||..:::.|::.|.   :.:|:|      .:.:..||.::  .|..|.|:.||...
Yeast   391 FSNRFVGRVANGNNVVQFYKKRSPVTRSKKSGINGTSISDRDVEKLFSE--SGGELEVQTLVNDL 453

Human   437 FQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQ-------LEKTQRFLKERHIDALE 494
            .    ..:|||||.|.|:.|||::||||:||.|::|.:.::       |...:.||  |..||.|
Yeast   454 L----NKMQLSLLPEVGLNEAVKKFVDKDEKTALKEFISHEISNEVGILSTNEEFL--RTDDAEE 512

Human   495 DK-IDEEVRRFRETRQKNTNEEDD------------------EVR-------------------- 520
            .| :.::|:|....|.....|.|:                  |||
Yeast   513 MKALIKQVKRANSVRPTPPKENDETNFAFNGNGLDSFRSSNREVRTGSPDITQSHVDNESRITHI 577

Human   521 ------EAMTRARALRSQSEESASAFSADDLMSIDLAEQMA--NDSDDSISAATN---------- 567
                  :..::.:.:|:.:::...|||...::| |...::.  ||:.|.:....|
Yeast   578 SQAESSKPTSKPKRVRTATKKKIPAFSDSTVIS-DAENELGDNNDAQDDVDIDENDIIMVSTDEE 641

Human   568 -------KGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSAS 615
                   .||......|......:|||.|  :|||         ||..||.:..|
Yeast   642 DASYGLLNGRKTKTKTRPAASTKTASRRG--KGRA---------SRTPKTDILGS 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
MRE11	NP_013951.1	mre11	6..413	CDD:273153	187/433 (43%)