Protein Alignment MRE11 and Mre11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_071615.1
• Gene: Mre11 / 64046
• RGDID: 69263
• Length: 706
• Species: Rattus norvegicus
• Alignment Length: 726
• Identity: 626/726 - (86%)
• Similarity: 664/726 - (91%)
• Gaps: 21/726 - (2%)

Human     1 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHEN 65
            ||..|.||||:||||||||||||||||||||||||||||.|||||||.|||||||||||||||||
  Rat     1 MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHEN 65

Human    66 KPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHD 130
            ||||||||:|||||||||||||||||||:|||||||||||||||||:||||||||||||||||||
  Rat    66 KPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYRDGNLNISIPVFSIHGNHD 130

Human   131 DPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVN 195
            ||||||||||||:||||||||||||||||||:|||||||||||||:|||||||||||||||||||
  Rat   131 DPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVN 195

Human   196 KKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQL 260
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||:|||||
  Rat   196 KKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQL 260

Human   261 FYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDN 325
            ||:|||||||||:|||||.|||||||||:|||||||.|:||.|||||||||:||||||.:|||||
  Rat   261 FYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDN 325

Human   326 PKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVA 390
            |||||||||||||||||||::||||||||..||||||:|||||||||||||:|||||||||||||
  Rat   326 PKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVA 390

Human   391 NPKDIIHFFRHREQKEKTGEEINFGKLITKP-SEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGM 454
            ||||:||||||||||.||||||||||||.|| |||||||||||||||||||||||||||||||||
  Rat   391 NPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGM 455

Human   455 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEV 519
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||:|||||||||
  Rat   456 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEV 520

Human   520 REAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNS 584
            ||||:||||||||||.:||||||||| |.|:.||.|:|||||.||..::||||||||||||||::
  Rat   521 REAMSRARALRSQSENAASAFSADDL-SFDITEQTADDSDDSQSAVPSRGRGRGRGRRGGRGQST 584

Human   585 ASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDES 649
            |.|||||||| ||||..|||.|:||...|.||||||||||:||||||||||.||||||.||||||
  Rat   585 APRGGSQRGR-DTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYSETIEVDES 648

Human   650 DVEEDIFPTTSKTDQRKGDLLEDYRDTSGFGRKWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPF 714
            | ::|.|||:|:.|||                 ||.|:.||.|||||.:|||||||.||||||||
  Rat   649 D-DDDSFPTSSRADQR-----------------WSGTAPSKRMSQSQTAKGVDFESDEDDDDDPF 695

Human   715 MNTSSLRRNRR 725
            |:.|..|||||
  Rat   696 MSGSCPRRNRR 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
Mre11	NP_071615.1	mre11	10..402	CDD:273153	363/391 (93%)
		Interaction with NBN. /evidence=ECO:0000250|UniProtKB:P49959	87..117		27/29 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..706		154/220 (70%)
		GAR. /evidence=ECO:0000250|UniProtKB:P49959	570..594		20/23 (87%)