Protein Alignment MRE11 and mre11a

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_001307188.1
• Gene: mre11a / 406637
• ZFINID: ZDB-GENE-040426-2638
• Length: 700
• Species: Danio rerio
• Alignment Length: 726
• Identity: 458/726 - (63%)
• Similarity: 572/726 - (78%)
• Gaps: 33/726 - (4%)

Human     2 STADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENK 66
            |....:|||:|||||:|||||||::||||:||||||||.|||::.|.:|||||:||||||||:||
Zfish     3 SAGSTVDDEDTFKILIATDIHLGYLEKDAIRGNDTFVTFDEIMKQAMQNEVDFVLLGGDLFHDNK 67

Human    67 PSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDD 131
            |||||:|:|:|::|||||||||:.|||:|||:|||..|:||||||.|.|||||||:||:||||||
Zfish    68 PSRKTMHSCMEVMRKYCMGDRPIIFEIISDQAVNFSHSRFPWVNYLDDNLNISIPIFSVHGNHDD 132

Human   132 PTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNK 196
            |||:|.|||:|:|||||.|||||||.||||::|||||||||.|:||||||||||||||||||||.
Zfish   133 PTGSDGLCAVDLLSCAGLVNHFGRSRSVEKVEISPVLLQKGDTRIALYGLGSIPDERLYRMFVNN 197

Human   197 KVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLF 261
            :||||||:|||:.|||||||||||||||:||:|||||||||:|||:|||||||||||.:||||||
Zfish   198 QVTMLRPREDEDGWFNLFVIHQNRSKHGATNYIPEQFLDDFLDLVVWGHEHECKIAPVRNEQQLF 262

Human   262 YISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNP 326
            |::||||||:||||||||||||:||||:||:|||:.||||.||||||::|:||:::|::|:|:.|
Zfish   263 YVTQPGSSVITSLSPGEAVKKHIGLLRVKGKKMNLQKIPLQTVRQFFIQDVVLSDYPELFSPEQP 327

Human   327 KVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVAN 391
            .....:|:||.||:|||||.||||||||...|||||:|||||||||||.|:.:||||||||:|||
Zfish   328 NTMLKVQAFCQEKVEEMLEEAERERLGNPQIPEKPLIRLRVDYSGGFEVFNTMRFSQKFVDKVAN 392

Human   392 PKDIIHFFRHREQKEK-TGEEINFGKLITKP-SEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGM 454
            ||||:||.||||.|.. ..|:::|..|.::| ||...||||||||:||||||||||||||||:||
Zfish   393 PKDILHFVRHRETKGNIKDEDVDFEALFSRPTSEVLQLRVEDLVKEYFQTAEKNVQLSLLTEQGM 457

Human   455 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEV 519
            |:||||||||||:||||||:.||||||||:|:||.:||.|:|||||:|:||::: :||.|||:||
Zfish   458 GKAVQEFVDKEERDAIEELINYQLEKTQRYLRERRVDATEEKIDEEIRQFRDSK-RNTAEEDEEV 521

Human   520 REAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNS 584
            :||:.||:|.|.:.|.:..    |||...|....:|.:||:..|:|. ..||||||.||||...:
Zfish   522 QEAIIRAKAHRDRGETARD----DDLGLSDDPADIAMESDEEPSSAP-PVRGRGRGSRGGRDPCA 581

Human   585 ASRGGSQRGRADTGLETSTRSRNSKTAVSAS-RNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDE 648
                 |:||||......|.|....:.::|:. :..||:|.|:...|:.:|..|.|:|:|.|.:::
Zfish   582 -----SKRGRARGAASRSGRGGRGRGSLSSPVKTKSIMDVFQDVSQRSTRGKTPKSYAEEITIED 641

Human   649 SDVEEDI-FPTTSKTDQRKGDLLEDYRDTSGFGRKWSSTSSSKIMSQSQVSKGVDF-ESSEDDDD 711
            ||.:||: |..:|:|.|                 |..|.|.||..||||..|||.. |.|.:|:.
Zfish   642 SDSDEDVSFLKSSRTKQ-----------------KLPSLSDSKRASQSQSLKGVCIDEDSGEDEF 689

Human   712 DPFMNTSSLRR 722
            |||..:...||
Zfish   690 DPFKGSRKQRR 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
mre11a	NP_001307188.1	mre11	11..403	CDD:273153	300/391 (77%)