Protein Alignment MRE11 and mre11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 261/636 - (41%)
• Similarity: 368/636 - (57%)
• Gaps: 50/636 - (7%)

Human     2 STADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENK 66
            :|....|.:|..:||||||.|||:.|||||||.|:|...:|||.||...:||.|||||||||:..
  Fly     4 TTTAEQDADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAV 68

Human    67 PSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDD 131
            ||:..||.|:||||:|..|||||..||||||...|..:....|||:|.||||:||||||||||||
  Fly    69 PSQNALHKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDD 133

Human   132 PTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNK 196
            |:|...|.:||:||.:|.||:|||...:.:::|||||::||.:::|||||..|.|.||.|:..:.
  Fly   134 PSGFGRLSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDF 198

Human   197 KVTMLRPK-----------EDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECK 250
            ||....|:           ::|..||:|.|:||||:..|..|::||..|..|:.||||||||:|:
  Fly   199 KVKFNCPENVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCR 263

Human   251 IAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLA 315
            |.|.:|.::.||:|||||||.||||.|||.|||||||.|...|..:..:||.|||.|..|.:|||
  Fly   264 IEPEENAKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVVLA 328

Human   316 NHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLR 380
            :|.|.........:..:..|..|::|.|:|.|..:..|:..||..||:|||:.|:.....|:.:|
  Fly   329 DHADELGLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNAIR 393

Human   381 FSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGK-LITKPSEG-TTLRVEDLVKQYFQTAEKN 443
            |.:....||||.:|::.|  .:..|....|.:|..| .:.:..|. ...|||:||.:||:.|:.|
  Fly   394 FGEMLSTRVANVQDVVQF--SKVVKRTKTEAVNLDKEALRRALEADNATRVEELVDRYFEEAKSN 456

Human   444 VQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDAL------EDKIDEEVR 502
            ..|.|...:.:.|.....:::.:.||.|.:||        |.||:.:|.|      ::.||||:.
  Fly   457 KPLKLFHSKALAEMTYRLLEQRDADAAENIVK--------FYKEKAVDHLMEAMPNDENIDEELE 513

Human   503 RFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATN 567
            |||.     .::..|.::  |...:.|:.:.||.:        ||:     :.::.:.|.:.||.
  Fly   514 RFRA-----LHKHGDLLK--MLDTQGLKVKKEEKS--------MSV-----LGSEVNVSTAPATG 558

Human   568 KGRGRGRG-RRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRN 617
            :|..|||| .|...|..:|:||..|.....:...||.|.:...:::..|||
  Fly   559 RGAARGRGTARTRAGATAATRGKGQLDVTVSSTRTSGRQQTLLSSLMGSRN 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
mre11	NP_523547.1	mre11	13..413	CDD:273153	198/401 (49%)