Protein Alignment MRE11 and mre11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_592935.1
• Gene: mre11 / 2542757
• PomBaseID: SPAC13C5.07
• Length: 649
• Species: Schizosaccharomyces pombe
• Alignment Length: 685
• Identity: 259/685 - (37%)
• Similarity: 383/685 - (55%)
• Gaps: 66/685 - (9%)

Human     7 LDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKT 71
            |.:|||.:||:::|.|:|:.|||.|||||:||:.:|||.:|:|.:||.||||||:||:||||||.
pombe    12 LHNENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLGGDIFHDNKPSRKA 76

Human    72 LHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGAD 136
            |:..|..||..|:||:|.:.|:|||.|:..|.:....:||.|.|:|::|||||||||||||:|..
pombe    77 LYQALRSLRLNCLGDKPCELELLSDTSLTTGDTAVCNINYLDPNINVAIPVFSIHGNHDDPSGDG 141

Human   137 ALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTML 201
            ...|||||...|.||:|||....:.|.:||:|||||.||:||||:.::.|||||..|...||..|
pombe   142 RYSALDILQVTGLVNYFGRVPENDNIVVSPILLQKGFTKLALYGISNVRDERLYHSFRENKVKFL 206

Human   202 RPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQP 266
            ||....:.||||..:|||.|.|..|:::||.|:.||.|.|:|||||||.|..:.|..|.|.:.||
pombe   207 RPDLYRDEWFNLLTVHQNHSAHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQP 271

Human   267 GSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQA 331
            ||::.|||||||...||.|:|.|.|:..::.||.|.|||.|.|:||:|:....|  |...:..:.
pombe   272 GSTIATSLSPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSI--PPMVENKKE 334

Human   332 IQSFCLEKIEEMLENAER---ERLG-----NSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDR 388
            :.::.:.|:||.:..|..   |..|     .:.:|..||:||||||:||::..:..|||.:||.|
pombe   335 VLTYLISKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRLRVDYTGGYQTENPQRFSNRFVGR 399

Human   389 VANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEG---TTLRVEDLVKQYFQTAEKNVQLSLLT 450
            |||..|::.|:.   :|:.|..:.|.| |.|...|.   .:||||.||.:|.:|.    :|..|.
pombe   400 VANATDVVQFYL---KKKYTRSKRNDG-LYTSAVEDIKINSLRVESLVNEYLKTN----RLECLP 456

Human   451 ERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVR-------RFRETR 508
            |..:||||..||:|:::|||:|.|:.||.|....|.::.:  .|:.:::|:.       :...|:
pombe   457 EDSLGEAVVNFVEKDDRDAIKECVETQLNKQINLLVKKRV--TEENLEQEISSIINDLPKISTTK 519

Human   509 QKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAE-QMANDSDDSISAATNKGRGR 572
            :|:..|..:||.|............:.::|.......::...:| :|......::...|||.|
pombe   520 RKDYEELPEEVSETSINIAEHTPVLKHTSSLLDHHSPLATSSSEHEMEATPSPALLKKTNKRR-- 582

Human   573 GRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTT 637
                                     .|.:|...:|::|. ..|:.:..:.|.|.::.....:..|
pombe   583 -------------------------ELPSSLTKKNTRTP-QRSKEVKKVPARKLSQSTKKSDKNT 621

Human   638 KNYSEVIEVDESDVEEDIFPTTSKTDQRKGDLLED 672
            :  |.::..|.|...|     ....|....::|:|
pombe   622 Q--STLLFYDPSSTTE-----AQYLDNEDDEILDD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
mre11	NP_592935.1	mre11	15..414	CDD:273153	194/403 (48%)