Protein Alignment MRE11 and mre-11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_505736.2
• Gene: mre-11 / 179488
• WormBaseID: WBGene00003405
• Length: 728
• Species: Caenorhabditis elegans
• Alignment Length: 687
• Identity: 250/687 - (36%)
• Similarity: 371/687 - (54%)
• Gaps: 96/687 - (13%)

Human     8 DDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTL 72
            :.|:..|||||||||.|:.|..|....|...|.:|:|::|.|.:||.|||||||||||.|||:..
 Worm    61 ESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSREVQ 125

Human    73 HTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADA 137
            |...:|||:||:...|:..|.|||.||||..|.|..|||.|.|||:.:|:|:|||||||.:| ..
 Worm   126 HRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHDDLSG-KG 189

Human   138 LCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLR 202
            |.|||:|..:|.||.||:..::::..:||:||:||.|::||||:||..|:||.|.|.|..::.||
 Worm   190 LTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKNNSISFLR 254

Human   203 PKEDENSWFNLFVIHQNRSK---HGST-NFIPEQFLDDFIDLVIWGHEHECK-----IAPTKNEQ 258
            |......||||||:||||.:   |.|| ||:||..:..|.||:|||||||||     :|.::...
 Worm   255 PNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHEHECKPDPQYVASSEAVG 319

Human   259 QLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHP----D 319
            ..|||.||||:|.|||:|.||::|:..|::|||||.....|||.|||....::::|...|    .
 Worm   320 DGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVRPMVCDELLLDKIPPGSRP 384

Human   320 IFNPDNPKVTQA--IQSFCLE-KIEEMLENAERERLGNSHQPEKPLVRLRVDYSG---GFEPFSV 378
            |...|.||.|..  |....:| ||.||:..|:.:|  ...|||.||:||:|.|.|   ...|.:.
 Worm   385 ILKTDRPKHTDGRYIDEIAIEAKINEMITTAKAKR--RPRQPELPLIRLKVIYDGDWLNITPANA 447

Human   379 LRFSQKFVDRVANPKDIIHFFRHREQKE---KTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTA 440
            .|...::.:.|||..|::...::.:.||   :|..|.|..::..:..:.:...::.::..||...
 Worm   448 KRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQ 512

Human   441 EKNVQLSLLTERGMGEAVQEFVDKEEKDAIEE-------------LVKYQLEKTQRFLKERHIDA 492
            ....|:::|...|:|.|::::      .||||             .:.:|::..::.||:..:..
 Worm   513 PLVDQMTVLKPIGIGRALEQY------SAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPP 571

Human   493 LEDKIDEEVRRFRE--------------TRQKN------TNEEDDEVREAMTRARALRSQSEESA 537
            :.|..|  :.:||:              .|.||      ..|::|:.:..|..    :|.|..:.
 Worm   572 INDPSD--LDKFRDLITKDLYDMKKADSERFKNPVADVEMEEDEDDPQYYMPP----QSTSRTNY 630

Human   538 SAFSADDLMSIDLAEQMANDSDDSISAATNK--GRGRGRGRRGGRGQNSASRGGSQR----GRAD 596
            ::.|.|::.:.|  |:|.:    |||..:.:  .||||||.||.......:||.|.:    .:.|
 Worm   631 ASGSEDEVANSD--EEMGS----SISRHSKQPTTRGRGRGARGAGASRETTRGRSNKVVSTRQID 689

Human   597 T-GLE------------TSTRSR-NSKTAVSASRNMS 619
            : |.|            .|||.: ..|:|.|..|::|
 Worm   690 SDGFEIINDSPSPPPASRSTRGKARGKSAPSKKRDLS 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
mre-11	NP_505736.2	mre11	63..472	CDD:273153	189/411 (46%)