Protein Alignment MRE11 and Mre11a

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_061206.1
• Gene: Mre11a / 17535
• MGIID: 1100512
• Length: 706
• Species: Mus musculus
• Alignment Length: 726
• Identity: 625/726 - (86%)
• Similarity: 664/726 - (91%)
• Gaps: 21/726 - (2%)

Human     1 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHEN 65
            ||..|.||||:||||||||||||||||||||||||||||.|||||||.|||||||||||||||||
Mouse     1 MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHEN 65

Human    66 KPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHD 130
            ||||||||:||||||||||||||||||::||||||||||||||||||||||||||||||||||||
Mouse    66 KPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHD 130

Human   131 DPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVN 195
            ||||||||||||:||||||||||||||||||:|||||||||||||:|||||||||||||||||||
Mouse   131 DPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVN 195

Human   196 KKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQL 260
            |||||||||||||||||||||||||||||:||||||||||||||||||||||||||.|.||||||
Mouse   196 KKVTMLRPKEDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQL 260

Human   261 FYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDN 325
            ||:|||||||||||||||||||||||||||||||||.|:||.|||:||:||:||||||::|||||
Mouse   261 FYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDN 325

Human   326 PKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVA 390
            |||||||||||||||||||::||||||||..||.|||:|||||||||||||:|||||||||||||
Mouse   326 PKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVA 390

Human   391 NPKDIIHFFRHREQKEKTGEEINFGKLITKP-SEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGM 454
            ||||:||||||||||.|||||||||.||||| |||.|||||||||||||||||||||||||||||
Mouse   391 NPKDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLLTERGM 455

Human   455 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEV 519
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||:|||||||||
Mouse   456 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEV 520

Human   520 REAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNS 584
            ||||:||||||||||.|.|||||:|| |.|.:||.|||||||:||..::||||||||||.|||:|
Mouse   521 REAMSRARALRSQSETSTSAFSAEDL-SFDTSEQTANDSDDSLSAVPSRGRGRGRGRRGARGQSS 584

Human   585 ASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDES 649
            |.|||||||| |||||.:||.|:||...|.||||||||||:||||||||||..|||||.||||:|
Mouse   585 APRGGSQRGR-DTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVAPKNYSETIEVDDS 648

Human   650 DVEEDIFPTTSKTDQRKGDLLEDYRDTSGFGRKWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPF 714
            | |:|||||.|:.|||                 ||.|:|||.|||||.:|||||||.||||||||
Mouse   649 D-EDDIFPTNSRADQR-----------------WSGTTSSKRMSQSQTAKGVDFESDEDDDDDPF 695

Human   715 MNTSSLRRNRR 725
            |::|..|||||
Mouse   696 MSSSCPRRNRR 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
Mre11a	NP_061206.1	mre11	10..402	CDD:273153	362/391 (93%)
		Interaction with NBN. /evidence=ECO:0000250|UniProtKB:P49959	87..117		27/29 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..706		155/220 (70%)
		GAR. /evidence=ECO:0000250|UniProtKB:P49959	570..594		20/23 (87%)