Protein Alignment MRE11 and mre11

DIOPT Version :10

• Sequence 1: NP_001427389.1
• Gene: MRE11 / 4361
• HGNCID: 7230
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_001107519.1
• Gene: mre11 / 100135381
• XenbaseID: XB-GENE-957956
• Length: 709
• Species: Xenopus tropicalis
• Alignment Length: 728
• Identity: 524/728 - (71%)
• Similarity: 609/728 - (83%)
• Gaps: 25/728 - (3%)

Human     2 STADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENK 66
            |::..||||:||||||||||||||||||||||||:|.|.||||||||:|||||:||||||||:||
 Frog     3 SSSSCLDDEDTFKILVATDIHLGFMEKDAVRGNDSFSTFDEILRLAQDNEVDFLLLGGDLFHDNK 67

Human    67 PSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDD 131
            |||:|||.|||.||||||||||::||:|||||||||:||||||||||.|||||:||||:||||||
 Frog    68 PSRRTLHICLEQLRKYCMGDRPIEFEVLSDQSVNFGYSKFPWVNYQDNNLNISLPVFSVHGNHDD 132

Human   132 PTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNK 196
            |||||||||||||||||.||||||:.|||||||||||||||.:||||||||||||||||||||||
 Frog   133 PTGADALCALDILSCAGLVNHFGRATSVEKIDISPVLLQKGRSKIALYGLGSIPDERLYRMFVNK 197

Human   197 KVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLF 261
            :|.||||:|||:||||||||||||||||.||:|||||||||:||:||||||||||.||:||||||
 Frog   198 QVMMLRPREDESSWFNLFVIHQNRSKHGPTNYIPEQFLDDFLDLIIWGHEHECKINPTRNEQQLF 262

Human   262 YISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNP 326
            |:|||||||.||||||||.|||||||||||:||||.||||.||||||:||:||:::|||||||||
 Frog   263 YVSQPGSSVATSLSPGEAEKKHVGLLRIKGKKMNMQKIPLQTVRQFFIEDLVLSDYPDIFNPDNP 327

Human   327 KVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVAN 391
            ||||.|:|||:||:|.||:.||||||||:.||:|||:||||||:||||||:.||||||||||.||
 Frog   328 KVTQEIESFCIEKVEAMLDTAERERLGNARQPDKPLIRLRVDYTGGFEPFNTLRFSQKFVDRTAN 392

Human   392 PKDIIHFFRHREQKEKTGE-EINFGKLITKP-SEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGM 454
            ||||||||||:|||:|... .||||||.:|| .||:|||||||||:||:||||||||||||||||
 Frog   393 PKDIIHFFRHKEQKDKKDNITINFGKLDSKPLFEGSTLRVEDLVKEYFKTAEKNVQLSLLTERGM 457

Human   455 GEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEV 519
            |||||||||||||||:|||||:||||||||||||.|||.|||||||||:|||||:.|||||::||
 Frog   458 GEAVQEFVDKEEKDALEELVKFQLEKTQRFLKERQIDAEEDKIDEEVRKFRETRKTNTNEEEEEV 522

Human   520 REAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNS 584
            ||||.||||.|||:.:  ...|.||.:...::..:::|.|...|... :||||||| ||||||.:
 Frog   523 REAMIRARAHRSQTAD--IDMSDDDELMRKVSGPLSDDEDIGASMPA-RGRGRGRG-RGGRGQTT 583

Human   585 ASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFK-STRQQPSRNVTTKNYSEVIEVDE 648
            .:||.|:|||...|.:..:..|.||   :|.:||||:|||| |:||..:||:..|.|||.||.|:
 Frog   584 TTRGTSRRGRGSAGADQPSSGRASK---AAGKNMSILDAFKPSSRQPTARNMPKKTYSEDIEDDD 645

Human   649 SDVEEDIFPTTSKTDQRKGDLLEDYRDTSGFGRKWSSTSSSKIMSQSQVSKGVDFESSEDDDD-D 712
            ||:||..|..:|..:.|:         ||.     :|||.|:..||||.:||...:..:|:|: |
 Frog   646 SDIEEVSFTPSSFVESRR---------TSS-----TSTSYSRKSSQSQAAKGHFLDDDDDEDEFD 696

Human   713 PFMNTSSLRRNRR 725
            ||..::..||.||
 Frog   697 PFKKSAPSRRGRR 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRE11	NP_001427389.1	None
mre11	NP_001107519.1	mre11	11..403	CDD:273153	333/391 (85%)