Protein Alignment hdc and heca

DIOPT Version :9

• Sequence 1: NP_788768.1
• Gene: hdc / 43604
• FlyBaseID: FBgn0010113
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001038591.1
• Gene: heca / 567088
• ZFINID: ZDB-GENE-041001-173
• Length: 523
• Species: Danio rerio
• Alignment Length: 674
• Identity: 195/674 - (28%)
• Similarity: 271/674 - (40%)
• Gaps: 210/674 - (31%)

  Fly     4 RRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQGTGG-----VGGVG 63
            :||...:|||:..:                       ...::|||       |||     .|...
Zfish    10 KRNKRTNSSGDEQE-----------------------NGASASGV-------TGGTASTLTGATA 44

  Fly    64 GGGMVHCCLPSGDCRK--------LDTLIHLNELSLADCIRVLCNNENCSAGQYMHRECFEWWEA 120
            |        |..|.|.        :.:|....:|...|..||:||:|.|..|.:||.:||..||:
Zfish    45 G--------PPSDNRSEAPCATPLVCSLGRPVDLEKDDYQRVVCNSELCPYGNWMHLQCFYEWES 101

  Fly   121 SVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQLRKDLDWVPPSSQGVIYLNG 185
            |:|......||||||:|:|..|::||||||:|..:.|||:||:|.|:||.||......
Zfish   102 SILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRM------- 159

  Fly   186 SGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGG-------GGGGAGVNGNTKTPLSNNNGNS 243
                         :|:.|||..:|         |.|       |||..|.......|
Zfish   160 -------------QDERKKKMPEK---------GSGKLSSMACGGGACGGPETADEP-------- 194

  Fly   244 YAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNTNNVLGLDLRARA 308
                               ..|.:.::....:.|||..|.....|.:.|...         |..|
Zfish   195 -------------------KKGKSPASHKLAHRGSSQELSRRQSADWQNCQE---------RCHA 231

  Fly   309 GSLS-----SSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAFGSNLLQN 368
            |.|:     |.|..|...||:.|..||..|.||                  ||||....|..|..
Zfish   232 GPLNAVGGMSHGLRSPCESPAQSPPSGFSSFSP------------------QPLGGPRSSRHLGE 278

  Fly   369 GLGLSKNLLIAPQQQQQQQ---------LQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKN 424
            .|   ||.:.....::..|         |.:|......||.|.|     |:.
Zfish   279 FL---KNAVHTEGHKKHFQAGGLVGRGALLEQGAANMCLPRLDN-----PVQ------------- 322

  Fly   425 KEVELYSDRVRSTSGCNGIFSRRLDFSS-FNLLPKTRLNSYQVKIEDEGNHG-NDETRLFILSSL 487
                               |.||||.|. ...:|:.:||:|.|::||:...| .::.|.||||:|
Zfish   323 -------------------FLRRLDLSELLTHIPRHKLNTYHVRMEDDAQAGQGEDLRKFILSAL 368

  Fly   488 AQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKY------EGRTLYLTCVCMS 546
            :.|..:.|.|.||...|.:|:::|||||:.||||.:|.    |::|      :||.::|..:|:.
Zfish   369 SASHRNVVNCALCHHTLPIFEQFPLVDGTLFLSPSRHD----EIEYDVPCHLQGRLMHLYAICVD 429

  Fly   547 CLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFY 611
            ||:|.   ..|.|..||..||||...|||||.|||.||.|||..|..|.:|.|.::..:..:.::
Zfish   430 CLEGV---HKIVCIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRVGMQYF 491

  Fly   612 SDYSHGVTCPYCNTQDTHFVKPLT 635
            |:||:...||:|...|.|||||.:
Zfish   492 SEYSNVQQCPHCGNLDYHFVKPFS 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hdc	NP_788768.1	HECA	69..172	CDD:291998	46/110 (42%)
		Headcase	444..634	CDD:292621	82/197 (42%)
heca	NP_001038591.1	HECA	55..153	CDD:291998	43/97 (44%)
		Headcase	323..514	CDD:292621	82/197 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592037
Domainoid	1	1.000	162	1.000	Domainoid score	I3961
eggNOG	1	0.900	-	-		E1_KOG3816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3525
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008043
OrthoInspector	1	1.000	-	-		oto40351
orthoMCL	1	0.900	-	-		OOG6_109261
Panther	1	1.100	-	-	LDO	PTHR13425
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3611
SonicParanoid	1	1.000	-	-		X6000
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.780