DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hdc and HECA

DIOPT Version :9

Sequence 1:	NP_788768.1	Gene:	hdc / 43604	FlyBaseID:	FBgn0010113	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_057301.1	Gene:	HECA / 51696	HGNCID:	21041	Length:	543	Species:	Homo sapiens

Alignment Length:	673	Identity:	184/673 - (27%)
Similarity:	269/673 - (39%)	Gaps:	189/673 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAP---------MQGTGGV 59
            |:|...:|||:            :.:.....|....|....:.|.|.|.         ..|.||.
Human    11 RKNKRANSSGD------------EQENGAGALAAAGAAGAAAGGALAAAAGCGAAAAGAPGAGGA 63

  Fly    60 GGVGGGG-------MVHCCLPSGDCRKLDTLIHLNELSLA----------------DCIRVLCNN 101
            .|.||.|       .......:||.:        ||...|                |..:|:|||
Human    64 AGAGGAGTGAANAAAAAGAAAAGDAK--------NEAPCATPLICSFGRPVDLEKDDYQKVVCNN 120

  Fly   102 ENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQL 166
            |:|....:||.:||..||:|:|......||||||:|:|..|::||||||:|..:.|||:||:|.|
Human   121 EHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHL 185

  Fly   167 RKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGN 231
            :||.||......                    :|:.|||:      .:..|.|...|..|.....
Human   186 KKDTDWYQVKRM--------------------QDEKKKKS------GSEKNTGRPPGEAAEEAKK 224

  Fly   232 TKTPLSNNNGNSYAGLTPNPNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILNT 296
            .:.|.....|.|:              .||..:.....|.
Human   225 CRPPNKPQKGPSH--------------DLPRRHSMDRQNS------------------------- 250

  Fly   297 NNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPAF 361
                    :.:|...::.||.|...||..|..:|...:||.....|:..:.         ||
Human   251 --------QEKAVGAAAYGARSPGGSPGQSPPTGYSILSPAHFSGPRSSRY---------LG--- 295

  Fly   362 GSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPL-ASYEQQQLVQQQKNK 425
              ..|:|.:.|.      |.::                |:|....|:.. ..|....|...:...
Human   296 --EFLKNAIHLE------PHKK----------------AMAGGHVFRNAHFDYSPAGLAVHRGGH 336

  Fly   426 EVELYSDRVRSTSGCNGIFSRRLDFSS-FNLLPKTRLNSYQVKIEDEGNHG-NDETRLFILSSLA 488
                :...|:        |.||||.|. ...:|:.:||::.|::||:...| .::.|.|||::|:
Human   337 ----FDTPVQ--------FLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALS 389

  Fly   489 QSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKY------EGRTLYLTCVCMSC 547
            .|..:.|.|.||...|.||:::|||||:.||||.:|.    |::|      :||.::|..||:.|
Human   390 ASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHD----EIEYDVPCHLQGRLMHLYAVCVDC 450

  Fly   548 LDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQRLSFYS 612
            |:|.   ..|.|..||..||||...|||||.|||.||.|||..|..|.:|.|.::..:..:.::|
Human   451 LEGV---HKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGMQYFS 512

  Fly   613 DYSHGVTCPYCNTQDTHFVKPLT 635
            :||:...||:|...|.|||||.:
Human   513 EYSNVQQCPHCGNLDYHFVKPFS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hdc	NP_788768.1	HECA	69..172	CDD:291998	45/118 (38%)
hdc	NP_788768.1	Headcase	444..634	CDD:292621	82/197 (42%)
HECA	NP_057301.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/26 (19%)
		HECA	93..191	CDD:291998	41/97 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..283		23/158 (15%)
		Headcase	343..534	CDD:292621	82/197 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156412
Domainoid	1	1.000	160	1.000	Domainoid score	I4075
eggNOG	1	0.900	-	-		E1_KOG3816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3039
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008043
OrthoInspector	1	1.000	-	-		oto88989
orthoMCL	1	0.900	-	-		OOG6_109261
Panther	1	1.100	-	-	LDO	PTHR13425
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3611
SonicParanoid	1	1.000	-	-		X6000
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780