Protein Alignment hdc and Heca

DIOPT Version :9

• Sequence 1: NP_788768.1
• Gene: hdc / 43604
• FlyBaseID: FBgn0010113
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001028604.1
• Gene: Heca / 380629
• MGIID: 2685715
• Length: 544
• Species: Mus musculus
• Alignment Length: 678
• Identity: 186/678 - (27%)
• Similarity: 267/678 - (39%)
• Gaps: 198/678 - (29%)

  Fly     4 RRNSNISSSGNSTQQQHQQQLQQQHQTQQHQLLQFYAENVNSSGVLMAPMQ----------GTGG 58
            |:|...:|||:            :.:.....|....|....:.|.|.|...          ||||
Mouse    11 RKNKRANSSGD------------EQENGAGALAAAGATGAAAGGALAAAAAGCGAASPGAVGTGG 63

  Fly    59 VGGVGGGG-------MVHCCLPSGDC---------------RKLDTLIHLNELSLADCIRVLCNN 101
            ..|.||.|       :......:||.               |.:|       |...|..:|:|||
Mouse    64 AAGPGGAGTGAANATVAAGAAAAGDAKNGAPCATPLICSFGRPVD-------LEKDDYQKVVCNN 121

  Fly   102 ENCSAGQYMHRECFEWWEASVLQALKANGRARSWSERQRLQHLWTKKGYELVQKACSCKCGRGQL 166
            |:|....:||.:||..||:|:|......||||||:|:|..|::||||||:|..:.|||:||:|.|
Mouse   122 EHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHL 186

  Fly   167 RKDLDWVPPSSQGVIYLNGSGNRPTLANGSLSEDDDKKKAKKKRNRNNNNNNGGGGGGGAGVNGN 231
            :||.||......                    :|:.|||                    :|...|
Mouse   187 KKDTDWYQVKRM--------------------QDEKKKK--------------------SGSEKN 211

  Fly   232 TKTPLSNNNGNSYAGLTPN-PNVGVIGSGLPHNNGNTASNGSSGNNGSSGVLQTSALATFSNILN 295
            |..|.......:..|...| |..| :...||..:.....|......||
Mouse   212 TARPPGEAGEEAKKGRALNKPQKG-LNHDLPRRHSMDRQNSQEKTVGS----------------- 258

  Fly   296 TNNVLGLDLRARAGSLSSSGAGSGSTSPSDSQSSGEISVSPVQQLLPQQQQQQQQSLLIQPLGPA 360
                            ::.||.|...||..|..:|...:||.....|:..:.         ||
Mouse   259 ----------------AAYGARSPCGSPGQSPPTGYSILSPAHFSGPRSSRY---------LG-- 296

  Fly   361 FGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISNFKPLASYEQQQLVQQQKNK 425
               ..|:|.:.|                   :..:..:|......|    |.::
Mouse   297 ---EFLKNAIHL-------------------EPHKKAVPGGHVFRN----AHFD----------- 324

  Fly   426 EVELYSDRVRSTSGCNGI-----FSRRLDFSS-FNLLPKTRLNSYQVKIEDEGNHG-NDETRLFI 483
                ||....|.......     |.||||.|. ...:|:.:||::.|::||:...| .::.|.||
Mouse   325 ----YSSAGLSVHRAGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFI 385

  Fly   484 LSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKY------EGRTLYLTC 542
            |::|:.|..:.|.|.||...|.||:::|||||:.||||.:|.    |::|      :||.::|..
Mouse   386 LAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHD----EIEYDVPCHLQGRLMHLYA 446

  Fly   543 VCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQQR 607
            ||:.||:|.   ..|.|..||..||||...|||||.|||.||.|||..|..|.:|.|.::..:..
Mouse   447 VCVDCLEGV---HKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG 508

  Fly   608 LSFYSDYSHGVTCPYCNTQDTHFVKPLT 635
            :.::|:||:...||:|...|.|||||.:
Mouse   509 MQYFSEYSNVQQCPHCGNLDYHFVKPFS 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hdc	NP_788768.1	HECA	69..172	CDD:291998	45/117 (38%)
		Headcase	444..634	CDD:292621	82/197 (42%)
Heca	NP_001028604.1	HECA	94..192	CDD:291998	43/104 (41%)
		Headcase	344..535	CDD:292621	82/197 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846817
Domainoid	1	1.000	160	1.000	Domainoid score	I4057
eggNOG	1	0.900	-	-		E1_KOG3816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2994
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008043
OrthoInspector	1	1.000	-	-		oto92556
orthoMCL	1	0.900	-	-		OOG6_109261
Panther	1	1.100	-	-	LDO	PTHR13425
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3611
SonicParanoid	1	1.000	-	-		X6000
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780