DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hdc and cri-1

DIOPT Version :9

Sequence 1:	NP_788768.1	Gene:	hdc / 43604	FlyBaseID:	FBgn0010113	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001379194.1	Gene:	cri-1 / 187082	WormBaseID:	WBGene00010614	Length:	346	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	84/316 - (26%)
Similarity:	146/316 - (46%)	Gaps:	50/316 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 PQQQQQQQQSLLIQPLGPAFGSNLLQNGLGLSKNLLIAPQQQQQQQLQQQQQQQNNLPALANISN 406
            |.......|.:|::|                  .||.|.....|||....:::.|.|  ::|.|:
Worm    53 PDDDNYDSQLMLLKP------------------TLLAAATAANQQQNYDFRKRSNTL--MSNRSD 97

  Fly   407 FK-PLASYEQQ---------QLVQQQKNKEVELYSDRVRSTSGCNG-IFSRRLDFSS-FNLLPKT 459
            .: |......|         ::::...:::.....:.||    .|| :|.:|.|::: .:::|::
Worm    98 KRWPKRDMGPQFELRCCIDPEILRINVDRQYYFEDETVR----VNGSVFHKRSDYNNLLSVIPRS 158

  Fly   460 RLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQH 524
            :.|...:|:||:...|.|:.||.:|.||....:..:.|:.|::.|.|:|:|||:||.|::||...
Worm   159 KFNGIHIKMEDDCPQGGDDVRLCLLKSLGAHNLRAIPCVQCKDELKVYDKYPLIDGVFYISPVSQ 223

  Fly   525 SSGCIEVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFC-KEPW-DGSSLVLGTMYAYDIFAAMPC 587
            .....|:..:||..||..:|..||....|     |:.| |:.| ||.|.||||:|.|||.::..|
Worm   224 FGPKTEISLDGRRFYLQQLCARCLWSDWS-----CKNCGKDEWFDGKSFVLGTLYYYDIVSSGRC 283

  Fly   588 CAERFKCNNCFKML-----MHPQQRLSFYSDYSHGVTCPYCNTQDTHFVKPLTFCY 638
            |.  ..|.:|.:.|     :..|.....|:..:..:.|..|...:.|.|:.:..|:
Worm   284 CP--VVCQSCRQSLGVRDQLATQLANGNYATINEQMACQSCGVSNFHLVRDIKTCH 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hdc	NP_788768.1	HECA	69..172	CDD:291998
hdc	NP_788768.1	Headcase	444..634	CDD:292621	63/197 (32%)
cri-1	NP_001379194.1	Headcase	138..331	CDD:406412	64/199 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164199
Domainoid	1	1.000	117	1.000	Domainoid score	I3698
eggNOG	1	0.900	-	-		E1_KOG3816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008043
OrthoInspector	1	1.000	-	-		oto20130
orthoMCL	1	0.900	-	-		OOG6_109261
Panther	1	1.100	-	-	LDO	PTHR13425
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3611
SonicParanoid	1	1.000	-	-		X6000
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730