Protein Alignment CG9733 and TMPRSS3

DIOPT Version :10

• Sequence 1: NP_651784.2
• Gene: CG9733 / 43601
• FlyBaseID: FBgn0039759
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_076927.1
• Gene: TMPRSS3 / 64699
• HGNCID: 11877
• Length: 454
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 115/436 - (26%)
• Similarity: 174/436 - (39%)
• Gaps: 97/436 - (22%)

  Fly     8 FLCILIAHEAKAQSDSRCLNPNQTPGLCVLINECQTLYSVLKRATLTDQEKSFIKSSACGRGSNN 72
            |.||.:.......||.:   ..:....||.:.....:..|...|:.    |:.......|..:|
Human    83 FKCIELIARCDGVSDCK---DGEDEYRCVRVGGQNAVLQVFTAASW----KTMCSDDWKGHYAN- 139

  Fly    73 QPYVCCTQDTGYVRIQRQDRTFPDY--------GAFGGDWEEERPQSFV-----FPRQERRPWSF 124
               |.|.|           ..||.|        .:..|.:.||    ||     .|..:
Human   140 ---VACAQ-----------LGFPSYVSSDNLRVSSLEGQFREE----FVSIDHLLPDDK------ 180

  Fly   125 GNQPATSRTPFRKSSTSDGSSLLPQPPSCG-GVGIRNRIYDGQDTDVNEFPWMVLLEYRRRSGNG 188
              ..|...:.:.:...:.|..:..|..:|| ..|..:||..|..:.::::||...|:::   |..
Human   181 --VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQ---GYH 240

  Fly   189 LSTACAGSLINRRYVLTAAHC-----LTGRIEREVGTLVSVRLGEHDTRTAVDCPPGGGSCSPEV 248
            |   |.||:|...:::|||||     |......:|| |||:          :|        :|..
Human   241 L---CGGSVITPLWIITAAHCVYDLYLPKSWTIQVG-LVSL----------LD--------NPAP 283

  Fly   249 QRLGFEEIRVHERYSEKASNQVHDIGLIRMERNVRYSDNIQPICLPSSVGLESRQSGQQFTVAGW 313
            ..| .|:|..|.:|..|...  :||.|:::...:.:::.|||:|||:|.  |:...|:....:||
Human   284 SHL-VEKIVYHSKYKPKRLG--NDIALMKLAGPLTFNEMIQPVCLPNSE--ENFPDGKVCWTSGW 343

  Fly   314 GRTLKMA--RSAVKQKVTVNYVDPAKCRQR--FSQIKVNLEPTQLCA----GGQFRKDSCDGDSG 370
            |.|...|  .|.|.....|..:....|..|  :..|   :.|:.|||    ||   .|||.||||
Human   344 GATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGI---ISPSMLCAGYLTGG---VDSCQGDSG 402

  Fly   371 GPLMRFRDESWVLEGIVSFGYKCGLKDWPGVYTNVAAYDIWIRQNV 416
            |||:......|.|.|..|||..|...:.|||||.|.::..||.:.:
Human   403 GPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQM 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9733	NP_651784.2	CLIP	25..78	CDD:463440	8/52 (15%)
		Tryp_SPc	162..415	CDD:238113	84/265 (32%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060	5/26 (19%)
		SRCR_2	112..210	CDD:464747	22/128 (17%)
		Tryp_SPc	216..444	CDD:214473	83/263 (32%)