DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15531 and SCD

DIOPT Version :9

Sequence 1:	NP_651780.1	Gene:	CG15531 / 43592	FlyBaseID:	FBgn0039755	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_005054.3	Gene:	SCD / 6319	HGNCID:	10571	Length:	359	Species:	Homo sapiens

Alignment Length:	304	Identity:	90/304 - (29%)
Similarity:	156/304 - (51%)	Gaps:	21/304 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DQSGDSIHKKRDAIWPLVLFYIHLNILGVYGIYVLLTSASWATILFTALLTLLGTLGVTVGVHRL 74
            |:.|.|  .|.:.:|..::....|::..:||| .|:.:..:.|.|:......:..||:|.|.|||
Human    61 DKEGPS--PKVEYVWRNIILMSLLHLGALYGI-TLIPTCKFYTWLWGVFYYFVSALGITAGAHRL 122

  Fly    75 WAHRTFTASKPLKVFLMFCQTTAGQGSIYSVVQAHRLHHAKFQQDEDPYYSKHSFMYAQVRGGLL 139
            |:||::.|..||::||:...|.|.|..:|...:.||.||...:...||:.|:..|.::.|...|:
Human   123 WSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLV 187

  Fly   140 KYSPQQEELLKDVDMSDLESDPVVMFQKRFYVLLYIFLNVLLSVNTPFQYFGDSLATSMFVGFWL 204
            :..|..:|....:|:||||::.:||||:|:|....:.:..:|....|:.::|::...|:||..:|
Human   188 RKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFL 252

  Fly   205 RSLIVINLGNLVHSSHFIWSIHKGFKPTDSN---------SIFLITKSYWPQYHYLLPRDYQSGE 260
            |..:|:|...||:|:..::    |::|.|.|         |:..:.:.: ..||:..|.||.:.|
Human   253 RYAVVLNATWLVNSAAHLF----GYRPYDKNISPRENILVSLGAVGEGF-HNYHHSFPYDYSASE 312

  Fly   261 YGNYASGIGSSMIRVFAALDWAKDLKTIGSVAVRQGLTKAVETG 304
            | .:.....:..|...|||..|.|.|.:...|:   |.:...||
Human   313 Y-RWHINFTTFFIDCMAALGLAYDRKKVSKAAI---LARIKRTG 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15531	NP_651780.1	Delta9-FADS-like	49..286	CDD:239582	75/245 (31%)
SCD	NP_005054.3	Delta9-FADS-like	100..337	CDD:239582	75/242 (31%)
		FA_desaturase	102..306	CDD:278890	63/208 (30%)
		Histidine box-1. /evidence=ECO:0000305	120..125		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	157..161		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	298..302		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.837287	Normalized mean entropy	S1208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D971318at2759
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830