DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9747 and SCD5

DIOPT Version :9

Sequence 1:	NP_001287604.1	Gene:	CG9747 / 43591	FlyBaseID:	FBgn0039754	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_001032671.2	Gene:	SCD5 / 79966	HGNCID:	21088	Length:	330	Species:	Homo sapiens

Alignment Length:	389	Identity:	161/389 - (41%)
Similarity:	223/389 - (57%)	Gaps:	70/389 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PAIATDSSPPLVARRSKFPNGDAQQQVRRGEDSS-----PELP-PRGKLQLPPKREELPRSVVPK 73
            |..|||:        .|.|..||::::|.|.:||     ||.| .||:.|          ::|
Human     2 PGPATDA--------GKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQ----------NIV-- 46

  Fly    74 EIANHVPKDAIDLEEYTRTFVGDRVLGWQFQAPLKWDKVIQISLLHIVAGICLLTYPLRELNPYT 138
                                               |..|:.:||||:.|...|:..|  :..|.|
Human    47 -----------------------------------WRNVVLMSLLHLGAVYSLVLIP--KAKPLT 74

  Fly   139 TIWSFFVGGVAGFGVTAGAHRFWTHKSYKANTVLRSILMVCYCVAGQNTLYDWVRDHRVHHKYSE 203
            .:|::|...:|..||||||||.|:|:||:|...||..|.|...:|.||.:::|.||||.||||||
Human    75 LLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSE 139

  Fly   204 TDADPHNANRGFFFSHVGWLMMLKHPEVLRRGRQIDMSDILADPVVRFHQKYFIPLKTFFCFILP 268
            ||||||||.|||||||:|||.:.||.:|:.:||::|::|:|||||||..:||:.......||::|
Human   140 TDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVP 204

  Fly   269 TVIPVYCWGET-WTLAFIQQCLFRYVSSLNFTWSVNSAAHLWGSRPYDKRIMPSENIYVSLLAMG 332
            |::|.|.|||: |...|:...| ||..|||.:|.||||||::|:|||||.|.|.:|..|:|.|:|
Human   205 TLVPWYIWGESLWNSYFLASIL-RYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIG 268

  Fly   333 EGWHNYHHVFPWDYKAAELGNYTVNF--TTMVLDAFHKLGWAWNMKQPSKELVRRTLEKYGDGT 394
            ||:|||||.||:||.|:|.|   :||  ||..:|....||.|.:.|:.:|.::.....:.||.:
Human   269 EGFHNYHHTFPFDYSASEFG---LNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9747	NP_001287604.1	Delta9-FADS-like	135..376	CDD:239582	129/243 (53%)
CG9747	NP_001287604.1	FA_desaturase	140..343	CDD:278890	112/203 (55%)
SCD5	NP_001032671.2	Delta9-FADS-like	71..311	CDD:239582	129/243 (53%)
		FA_desaturase	77..279	CDD:278890	112/202 (55%)
		Histidine box-1. /evidence=ECO:0000305	94..99		3/4 (75%)
		Histidine box-2. /evidence=ECO:0000305	131..135		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	272..276		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930