DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9747 and SCD

DIOPT Version :9

Sequence 1:	NP_001287604.1	Gene:	CG9747 / 43591	FlyBaseID:	FBgn0039754	Length:	461	Species:	Drosophila melanogaster
Sequence 2:	NP_005054.3	Gene:	SCD / 6319	HGNCID:	10571	Length:	359	Species:	Homo sapiens

Alignment Length:	291	Identity:	145/291 - (49%)
Similarity:	193/291 - (66%)	Gaps:	7/291 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 WDKVIQISLLHIVA--GICLLTYPLRELNPYTTIWSFFVGGVAGFGVTAGAHRFWTHKSYKANTV 171
            |..:|.:||||:.|  ||.|:  |..:.  ||.:|..|...|:..|:||||||.|:|:||||...
Human    73 WRNIILMSLLHLGALYGITLI--PTCKF--YTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLP 133

  Fly   172 LRSILMVCYCVAGQNTLYDWVRDHRVHHKYSETDADPHNANRGFFFSHVGWLMMLKHPEVLRRGR 236
            ||..|::...:|.||.:|:|.||||.|||:|||.|||||:.|||||||||||::.|||.|..:|.
Human   134 LRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGS 198

  Fly   237 QIDMSDILADPVVRFHQKYFIPLKTFFCFILPTVIPVYCWGETWTLAFIQQCLFRYVSSLNFTWS 301
            .:|:||:.|:.:|.|.::|:.|.....||||||::|.|.||||:..:.......||...||.||.
Human   199 TLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWL 263

  Fly   302 VNSAAHLWGSRPYDKRIMPSENIYVSLLAMGEGWHNYHHVFPWDYKAAELGNYTVNFTTMVLDAF 366
            |||||||:|.|||||.|.|.|||.|||.|:|||:|||||.||:||.|:|. .:.:||||..:|..
Human   264 VNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEY-RWHINFTTFFIDCM 327

  Fly   367 HKLGWAWNMKQPSKELVRRTLEKYGDGTHAS 397
            ..||.|::.|:.||..:...:::.|||.:.|
Human   328 AALGLAYDRKKVSKAAILARIKRTGDGNYKS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9747	NP_001287604.1	Delta9-FADS-like	135..376	CDD:239582	127/240 (53%)
CG9747	NP_001287604.1	FA_desaturase	140..343	CDD:278890	111/202 (55%)
SCD	NP_005054.3	Delta9-FADS-like	100..337	CDD:239582	126/237 (53%)
		FA_desaturase	102..306	CDD:278890	112/203 (55%)
		Histidine box-1. /evidence=ECO:0000305	120..125		3/4 (75%)
		Histidine box-2. /evidence=ECO:0000305	157..161		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	298..302		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.837287	Normalized mean entropy	S1208
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880