DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1983 and PLPBP

DIOPT Version :9

Sequence 1:	NP_001287602.1	Gene:	CG1983 / 43588	FlyBaseID:	FBgn0039751	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001336275.1	Gene:	PLPBP / 11212	HGNCID:	9457	Length:	285	Species:	Homo sapiens

Alignment Length:	254	Identity:	124/254 - (48%)
Similarity:	180/254 - (70%)	Gaps:	12/254 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AEFDVKAGLQHVLKRIDEVLLQRPKEVQAARPLLVAVSKTKPAEAVIEAYEGGQRDFGENYVQEL 71
            ||..|...|:.|.:|:.:.:.:||:::.|.:|.||||||||||:.|||||..|||.|||||||||
Human     9 AELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQEL 73

  Fly    72 EEKSRHPDILAKCPDIRWHFIGHMQSNKINKILSVPNLHMIQTVDSEKLATKLDAAWSKRQPTPE 136
            .||:.:|.||:.||:|:||||||:|...:||:::||||.|::||||.|||.|::::| :|:.:||
Human    74 LEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSW-QRKGSPE 137

  Fly   137 EPLQVLIQINTSGEDV----------KSGIEAKDAPALYQYIKSNLKHLNLMGIMTIGAFGFDYS 191
            . |:|::|||||||::          |.|:...:..|:.::|.:...:|..:|:||||:||.|.|
Human   138 R-LKVMVQINTSGEEIYLFSVSFLEGKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLS 201

  Fly   192 NGPNPDFVSLMQVHRSICEAHSLAPDSVLVSMGMSNDFDKAIEMGSTVVRVGSSIFGHR 250
            .||||||..|:.:...:|:..::..|.|.:|||||.||..|:|:|||.||:||:|||.|
Human   202 QGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGER 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1983	NP_001287602.1	PLPDE_III_YBL036c_euk	15..248	CDD:143496	118/242 (49%)
PLPBP	NP_001336275.1	PLPDE_III_YBL036c_euk	17..258	CDD:143496	118/242 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158271
Domainoid	1	1.000	238	1.000	Domainoid score	I2308
eggNOG	1	0.900	-	-		E1_COG0325
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5211
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3170
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53991
OrthoDB	1	1.010	-	-		D1423577at2759
OrthoFinder	1	1.000	-	-		FOG0003600
OrthoInspector	1	1.000	-	-		oto90705
orthoMCL	1	0.900	-	-		OOG6_101083
Panther	1	1.100	-	-	LDO	PTHR10146
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2475
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770