Protein Alignment CG11498 and SPATA18

DIOPT Version :10

• Sequence 1: NP_001334706.1
• Gene: CG11498 / 43585
• FlyBaseID: FBgn0039749
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_660306.1
• Gene: SPATA18 / 132671
• HGNCID: 29579
• Length: 538
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 105/550 - (19%)
• Similarity: 195/550 - (35%)
• Gaps: 130/550 - (23%)

  Fly    36 FGAASMADSRERIRGPSRDGREFLTSPRQVLRRLMLLSEGRQYREAAGVVGRLGPSVLRSVIAEL 100
            ||..:.|..    .|...||.|.:.|      ||:      .:.||:.....||    :||.:::
Human    55 FGILTAAAQ----EGGRNDGVETIKS------RLL------PWLEASFTAASLG----KSVDSKV 99

  Fly   101 PLDLLLEHLPHSAYLLESFFTRLTTLNTTPKPDVPSETVAWQLVRLFANPHESGLRQRCTRLLQA 165
            |             .|:..|.|....:.:|:..        .:.:|.:|.:.:  |.:|.::...
Human   100 P-------------SLQDTFDRERHKDPSPRDR--------DMQQLDSNLNST--RSQCNQVQDD 141

  Fly   166 LAQYEPGLRQTLRERRRSFDNAVQGLGVHGLTTDASGQLISLHVALKTELQRHVDTYKMAIHKLE 230
            |.:.|..|.::   :.||                    .|||..|     :..::..|      :
Human   142 LVETEKNLEES---KNRS--------------------AISLLAA-----EEEINQLK------K 172

  Fly   231 ELSMVTVNQDPAHSSHQRLLAINYGDIQQRLIDN-KTLLTMLDKPALKQLQTLVENLSTRVENDK 294
            :|..:...:|..|.           :..||..:| ::....|::...:|..:|.:|..   :.|.
Human   173 QLKSLQAQEDARHR-----------NTDQRSSENRRSEPWSLEERKREQWNSLKQNAD---QQDT 223

  Fly   295 EVLT-CVGQVRRLDAQALVEKRPAAGLLMNFSRGCEVVLHMMGPEGGPPGSSHSIGKTTPPGGAS 358
            |.:: ...|:|.|..:..|.....:.|....||.       ..|...|...|.|..::..|..|.
Human   224 EAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRS-------RSPSPAPRSRSCSRSRSASPSTAV 281

  Fly   359 TSSCSDGYHSDDSGSDDSSEMVSLYRNLYVENRADA----LEALDSLPQIKHAHSLKGKILFSMI 419
            .........|..|.....:.::|.:.:.|.:.|.||    ...:|....::       :|::...
Human   282 KVRRPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQ-------RIIYIAT 339

  Fly   420 VLSFRLCHGMRERKVLEVRRVLNCPLDSSSETTLSLDRSVRQHLFETAESFPLGEIERSVFNQVL 484
            |.:|.:.........:.||:.|......|::...::...|..||       .|.:.:.|| |.|:
Human   340 VEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAVLDYVICHL-------DLYDSQSSV-NDVI 396

  Fly   485 STLHEYPCLESCPP------LTHYVSACVRLAWRMINQKAPYYLDMDFNLG--FLRPEKHERHPQ 541
            ..::..|.: |.||      |:.::.....:|:.|...:.|  ||:.:...  .....|:.|...
Human   397 RAMNVNPKI-SFPPVVDFCLLSDFIQEICCIAFAMQALEPP--LDIAYGADGEVFNDCKYRRSYD 458

  Fly   542 ADRRSDLIKAFLWPALMQNNQCAFKAVVAT 571
            :|..:.|:...:|||||:|:....|....|
Human   459 SDFTAPLVLYHVWPALMENDCVIMKGEAVT 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11498	NP_001334706.1	MIEAP	378..571	CDD:464982	42/204 (21%)
SPATA18	NP_660306.1	Interaction with YWHAG/14-3-3 protein gamma. /evidence=ECO:0000269|PubMed:22532927	1..273		58/315 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..137		9/62 (15%)
		COG4372	120..>251	CDD:443500	30/180 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..226		12/66 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..294		10/53 (19%)
		MIEAP	298..488	CDD:464982	42/207 (20%)