DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and GPR50

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens

Alignment Length:	790	Identity:	156/790 - (19%)
Similarity:	257/790 - (32%)	Gaps:	302/790 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM--GLPRNLHA 111
            |:..:|.:|||.:||:...:.:|||...|.::|||::||:||.....|..:.|..  |...:...
Human    36 VITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQ 100

  Fly   112 CL---FTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
            |.   |...|.||   .|||.:||::::||..|.:.:.|.|....|.....:.:.|:. |::..|
Human   101 CQMVGFITGLSVV---GSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIM-TVLAVL 161

  Fly   174 PLFGWHADVNHNQE---CLFVEVMDYNYL---------VFLYFATIITPALLMLAFYTHIYRVII 226
            |.. :...:.::..   |:|      |||         |.::|   :.|.|::...|..|:..::
Human   162 PNM-YIGTIEYDPRTYTCIF------NYLNNPVFTVTIVCIHF---VLPLLIVGFCYVRIWTKVL 216

  Fly   227 KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMI 291
             ..|.....||.:.|:                                :|:....:.:|.|.|.:
Human   217 -AARDPAGQNPDNQLA--------------------------------EVRNFLTMFVIFLLFAV 248

  Fly   292 CWIPLYTINCIKAFCPDCYVHPK---------LTLFCIILSHLNSAVNPVLYAYHLKDFRA---- 343
            ||.|:..:..:.|      |.||         |.|....:::.||.:|.|:|....::||.
Human   249 CWCPINVLTVLVA------VSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWT 307

  Fly   344 ---ALKNLLLKMMGV--DIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQ 403
               |:::.::...|:  ||.:..||    ...::.|..:.|.                  .|:|.
Human   308 IFHAMRHPIIFFSGLISDIREMQEA----RTLARARAHARDQ------------------AREQD 350

  Fly   404 EALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPG 468
            .|       ..|..|.....|:..                   |.....|..|........|.|.
Human   351 RA-------HACPAVEETPMNVRN-------------------VPLPGDAAAGHPDRASGHPKPH 389

  Fly   469 SQRSSE-RNSSSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVPNPV 532
            |:.||. |.|:||                   :|...||..:               |:|
Human   390 SRSSSAYRKSAST-------------------HHKSVFSHSK---------------AAS----- 415

  Fly   533 QPGIDPVELRRSLALVMREKLRSDDTDSRPMGNNQDLPIDEQSRERPLSTQTSPTNG-------- 589
                                                      ...:|:|..:.|.:|
Human   416 ------------------------------------------GHLKPVSGHSKPASGHPKSATVY 438

  Fly   590 PLPALLRAKL----LAGNS-----NSAHCLPGSTASPAPQEQSGIFVIDSEASPGSNGHKPKYRK 645
            |.||.:..|.    ..|:|     :|.|..|.| ::|.|       :.....|.||:. |..:..
Human   439 PKPASVHFKADSVHFKGDSVHFKPDSVHFKPAS-SNPKP-------ITGHHVSAGSHS-KSAFSA 494

  Fly   646 GTAF---TRSSLKKSRSCNCSSIAKGRGVHDEPSSNLCRDQESSVLPQHPQP---------ANHP 698
            .|:.   |...:|.:.|            |.||::   .|........||:|         |:|.
Human   495 ATSHPKPTTGHIKPATS------------HAEPTT---ADYPKPATTSHPKPTAADNPELSASHC 544

  Fly   699 TENFFSPLRSVGSFMQHSNLFHFLQPHAARPTS--STASSTASTPT--PSPPPMGQAQEESV--- 756
            .|                      .|..|.|.|  |....:||:|.  |:.|...|.:.:::
Human   545 PE----------------------IPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADL 587

  Fly   757 --PVGLTTSS 764
              |..:|||:
Human   588 PDPTVVTTST 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/184 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/301 (23%)
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	47/172 (27%)
		7tm_1	45..294	CDD:278431	70/301 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438		28/222 (13%)
		DUF4045	<364..600	CDD:289995	67/380 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596		37/177 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910